Tyrphostin 1
SIGMA/T7040 - ≥98%
Synonym: (4-
CAS Number: 2826-26-8
Empirical Formula (Hill Notation): C11H8N2O
Molecular Weight: 184.19
MDL Number: MFCD00019787
Linear Formula: CH3OC6H4CH=C(CN)2
Product Type: Chemical
assay | ≥98% |
form | solid |
InChI | 1S/C11H8N2O/c1-14-11-4-2- |
InChI key | UOHFCPXBKJPCAD-UHFFFAOYSA |
mp | 113-116 °C (lit.) |
potency | >1250 μM IC50 (negative control) |
Quality Level | 200 ![]() |
SMILES string | COc1ccc(cc1)C=C(/C#N)C#N |
solubility | chloroform: soluble 50 mg/mL, clear, light yellow |
DMSO: soluble | |
storage temp. | 2-8°C |
Application: | Tyrphostin 1 has been used to study its effect on the increase of transgene expression in HeLa and NIH3T3 cells. |
Biochem/physiol Actions: | EGFR tyrosine kinase inhibitor. |
Biochem/physiol Actions: | Tyrphostin 1 is a small molecule inhibitor of epidermal growth factor (EGF) receptor kinase function. This molecule associates with the substrate subsite of the protein tyrosine kinase (PTK) domain. Tyrphostin 1 is also known to block EGF-dependent receptor autophosphorylation,. Furthermore, studies have reported that tyrphostin 1 can block Ca2+ channels and inhibit growth in vascular smooth muscle cells,. |
Features and Benefits: | This compound is a featured product for Kinase Phosphatase Biology research. Click here ![]() ![]() |
Packaging: | 25 mg in poly bottle |
Preparation Note: | Tyrphostin 1 dissolves in chloroform at 50 mg/ml to yield a clear, light yellow solution. It is also soluble in DMSO. |
RIDADR | NONH for all modes of transport |
WGK Germany | WGK 3 |
Flash Point(F) | Not applicable |
Flash Point(C) | Not applicable |
Purity | ≥98% |
mp | 113-116 °C (lit.) |
Storage Temp. | 2-8°C |
UNSPSC | 12352200 |