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Tazarotene

SIGMA/T7080 - ≥98% (HPLC)

Synonym: 6-[(3,4-Dihydro-4,4-dimethyl-2H-1-benzothiopyran-6-yl)ethynyl]-3-pyridinecarboxylic acid ethyl ester; AGN-190168; ethyl 6-[2-(4,4-dimethylthiochroman-6-yl)ethynyl] nicotinate

CAS Number: 118292-40-3
Empirical Formula (Hill Notation): C21H21NO2S
Molecular Weight: 351.46
Linear Formula: C21H21NO2S
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-T7080-10MG 10 mg
 $116.00
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45-T7080-50MG 50 mg
 $434.00
1/EA		 Add To Favorites
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assay ≥98% (HPLC)
color white to very faintly yellow
form powder
InChI 1S/C21H21NO2S/c1-4-24-20(23)16-7-9-17(22-14-16)8-5-15-6-10-19-18(13-15)21(2,3)11-12-25-19/h6-7,9-10,13-14H,4,11-12H2,1-3H3
InChI key OGQICQVSFDPSEI-UHFFFAOYSA-N
originator Allergan
Quality Level 100 
SMILES string S1CCC(c2c1ccc(c2)C#Cc3ncc(cc3)C(=O)OCC)(C)C
solubility DMSO: >15 mg/mL
storage temp. 2-8°C
Biochem/physiol Actions: Tazarotene induces the expression of tazarotene-induced gene 3 (TIG3), a tumor suppressor gene.
Biochem/physiol Actions: Tazarotene induces the expression of tazarotene-induced gene 3 (TIG3), a tumor suppressor gene. It is a prodrug of tazarotenic acid, which specifically activates RARb and RARg, only weakly activates RARa, and is inactive at retinoid X receptors (RXRs). In psoriasis, tazarotene normalizes abnormal keratinocyte differentiation and reduces their hyperproliferation.
Features and Benefits: This compound is a featured product for Gene Regulation research. Click here  to discover more featured Gene Regulation products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm .
Features and Benefits: This compound was developed by Allergan . To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here .
Packaging: 10, 50 mg in glass bottle
Purity ≥98% (HPLC)
Storage Temp. 2-8°C
UNSPSC 12352200

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