Tyr-Ile-Gly-Ser-Arg

SIGMA/T7154 - ≥97% (HPLC)

Synonym: Laminin Fragment 929-933

CAS Number: 110590-64-2
Empirical Formula (Hill Notation): C₂₆H₄₂N₈O₈
Molecular Weight: 594.66
MDL Number: MFCD00076472
Linear Formula: C₂₆H₄₂N₈O₈
Product Type: Chemical

Catalog Number	PKG Qty.	Price	Quantity


45-T7154-1MG	1 mg	$132.00 1/EA		Add To Favorites
45-T7154-5MG	5 mg	$439.00 1/EA		Add To Favorites

Properties
Descriptions
Safety Info.
Basic Data

assay	≥97% (HPLC)
biological source	synthetic (organic)
form	powder
InChI	1S/C26H42N8O8/c1-3-14(2)21(34-22(38)17(27)11-15-6-8-16(36)9-7-15)24(40)31-12-20(37)32-19(13-35)23(39)33-18(25(41)42)5-4-10-30-26(28)29/h6-9,14,17-19,21,35-36H,3-5,10-13,27H2,1-2H3,(H,31,40)(H,32,37)(H,33,39)(H,34,38)(H,41,42)(H4,28,29,30)/t14-,17-,18-,19-,21-/m0/s1
InChI key	MWOGMBZGFFZBMK-LJZWMIMPSA-N
Quality Level	200
SMILES string	CC[C@H](C)[C@H](NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)NCC(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(N)=N)C(O)=O
solubility	H₂O: soluble 1 mg/mL, clear, colorless
storage temp.	−20°C
technique(s)	cell culture \| mammalian: suitable

Amino Acid Sequence:	Tyr-Ile-Gly-Ser-Arg
Application:	Tyr-Ile-Gly-Ser-Arg (YIGSR) can be used at the interface between the conjugated polymer and the tissue for the engineering of tissue interface. The product can also be used to study the role of integrins β1, α6, and α3 in promoting type II epithelial differentiation during lung maturation in the fetus.
Biochem/physiol Actions:	Tyr-Ile-Gly-Ser-Arg (YIGSR) is a pentapeptide of the protein laminin that reduces the lung colony formation in mice administered with melanoma cells as well as can block the invasiveness of the cells in vitro. It inhibits the increased expression of endothelial nitric-oxide synthase in primary porcine aortic endothelial cells.
Biochem/physiol Actions:	Tyr-Ile-Gly-Ser-Arg is a fragment of domain III of the laminin B1 chain . It is a major receptor binding site in laminin. It competes with laminin for the cell surface receptor. It is an inhibitor of tumor growth and metastasis.
Preparation Note:	Tyr-Ile-Gly-Ser-Arg dissolves in water at 1 mg/ml to yield a clear, colorless solution.

RIDADR	NONH for all modes of transport
WGK Germany	WGK 3
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable

Purity	≥97% (HPLC)
Storage Temp.	−20°C
UNSPSC	12352200

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