Tyrphostin 23
SIGMA/T7165 - ≥98%
Synonym: (3,4-
CAS Number: 118409-57-7
Empirical Formula (Hill Notation): C10H6N2O2
Molecular Weight: 186.17
MDL Number: MFCD00133899
Linear Formula: C10H6N2O2
Product Type: Chemical
Representative of vacuum-sealed clear ampule packaging. Non-uniform tips are an inherent feature in this sealing process.
| assay | ≥98% |
| biological source | synthetic (organic) |
| form | powder |
| InChI | 1S/C10H6N2O2/c11-5-8(6-12 |
| InChI key | VTJXFTPMFYAJJU-UHFFFAOYSA |
| potency | 35 μM IC50 |
| Quality Level | 100  |
| SMILES string | Oc1ccc(cc1O)C=C(C#N)C#N |
| solubility | DMSO: soluble 50 mg/mL, clear, yellow to brownish-yellow |
| storage temp. | 2-8°C |
| Application: | Tyrphostin 23 can be used as a tyrosine kinase inhibitor for studying rat ghrelin-induced MAPK stimulation in GH3 cells. Tyrphostin 23 has also been used to analyze its effects on secretoneurin (SN)-induced chemotaxis of neutrophils. |
| Biochem/physiol Actions: | Tyrphostin 23 is a small molecule inhibitor of epidermal growth factor (EGF) receptor kinase function. This molecule associates with the substrate subsite of the protein tyrosine kinase (PTK) domain,. |
| Features and Benefits: | This compound is a featured product for Kinase Phosphatase Biology research. Click here to discover more featured Kinase Phosphatase Biology products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm . |
| Packaging: | 5, 25 mg in ampule |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Purity | ≥98% |
| Storage Temp. | 2-8°C |
| UNSPSC | 12352200 |