Tumor Necrosis Factor Soluble Receptor II (TNF sRII)/Fc Chimera human
SIGMA/T7189 - >95% (SDS-PAGE), recombinant, expressed in NSO cells, lyophilized powder, suitable for cell culture
MDL Number: MFCD02689206
Product Type: Chemical
assay | >95% (SDS-PAGE) |
biological source | human |
form | lyophilized powder |
impurities | endotoxin, tested |
mol wt | 52.6 kDa |
packaging | pkg of 50 μg |
potency | 0.004-0.016 mg per mL ED50 |
Quality Level | 200 ![]() |
recombinant | expressed in NSO cells |
storage condition | avoid repeated freeze/thaw cycles |
storage temp. | −20°C |
technique(s) | cell culture | mammalian: suitable |
UniProt accession no. | P20333 ![]() ![]() |
Analysis Note: | The biological activity is measured by its ability to neutralize the TNF-α mediated cytotoxicity in mouse L-929 cells in the presence of the metabolic inhibitor actinomycin D. |
Application: | Tumor Necrosis Factor Soluble Receptor II (TNF sRII)/Fc Chimera human can be used as a test compound for analyzing the interaction between tumor necrosis factor (TNF) and its two soluble receptors by using surface plasmon resonance (SPR) technique. |
Biochem/physiol Actions: | Tumor Necrosis Factor Soluble Receptor II (TNF sRII)/Fc Chimera human belongs to TNF family of receptors and mediates the metabolic effects of TNF-α. Tumor Necrosis Factor Soluble Receptor II blocks the TNF-α-induced apoptosis and hence regulates the TNF-α function. It also has a pivotal role in neutralizing the biological activities of both TNF-α and TNF-β. |
Physical form: | Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline |
RIDADR | NONH for all modes of transport |
WGK Germany | WGK 3 |
Flash Point(F) | Not applicable |
Flash Point(C) | Not applicable |
Purity | >95% (SDS-PAGE) |
Storage Temp. | −20°C |
UNSPSC | 51111800 |