Paclitaxel
SIGMA/T7191 - from semisynthetic, ≥97%
CAS Number: 33069-62-4
Empirical Formula (Hill Notation): C47H51NO14
Molecular Weight: 853.91
MDL Number: MFCD00869953
Linear Formula: C47H51NO14
Product Type: Chemical
antibiotic activity spectrum | neoplastics |
assay | ≥97% |
biological source | semisynthetic |
impurities | natural taxane impurities, none detected (except ≤0.5% paclitaxel degradation products.) |
InChI | 1S/C47H51NO14/c1-25-31(60 |
InChI key | RCINICONZNJXQF-MZXODVADSA |
mode of action | DNA synthesis | interferes |
mp | 213 °C (dec.) (lit.) |
originator | Bristol-Myers Squibb |
Quality Level | 100 |
SMILES string | [H][C@@]12C[C@H](O)[C@@]3 |
solubility | DMSO: soluble 50 mg/mL |
ethanol: soluble | |
H2O: soluble (hydrolyzes) | |
methanol: soluble 50 mg/mL, clear, colorless | |
storage temp. | −20°C |
Application: | Paclitaxel has been used to study its effects on tumor regression in mouse models of pancreatic ductal adenocarcinoma. Paclitaxel has also been used as an internal standard for chromatographic assays of docetaxel. Furthermore, paclitaxel has been used to analyze its effects on Caenorhabditis elegans embryos. |
Biochem/physiol Actions: | Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase. The microtubule damage induces apoptosis through a JNK-dependent pathway followed by a JNK-independent pathway, perhaps related to the activation of protein kinase A (PKA) or of Raf-1 kinase, resulting in phosphorylation of Bcl-2. A major metabolite via CYP2CB is 6α-hydroxypaclitaxel (6α-OHP). |
Biochem/physiol Actions: | Paclitaxel is highly lipophilic. It serves as a substrate for p-glycoprotein, a multi-drug resistance protein. Paclitaxel is thus, less localized to the brain. Apart from its cytocidal action, paclitaxel is known to stimulate tumor invasion process. |
Caution: | Paclitaxel undergoes transesterification in methanol and hydrolyzes in aqueous solutions. |
Features and Benefits: | This compound is a featured product for ADME Tox research. Click here to discover more featured ADME Tox products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm . |
Features and Benefits: | This compound was developed by Bristol-Myers Squibb . To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here . |
General description: | Chemical structure: taxoide |
Packaging: | 1, 5, 25 mg in glass insert |
Preparation Note: | Paclitaxel is soluble in methanol at 50 mg/ml and yields a clear, colorless solution. It is also soluble in ethanol, water and DMSO. |
Symbol | GHS05,GHS07,GHS08 |
Signal word | Danger |
Hazard statements | H315 - H317 - H318 - H334 - H335 - H340 - H360D - H372 |
Precautionary statements | P201 - P280 - P302 + P352 - P304 + P340 + P312 - P305 + P351 + P338 - P308 + P313 |
Hazard Codes | Xn |
Risk Statements | 37/38-41-42/43-62-68 |
Safety Statements | 22-26-36/37/39-45 |
RIDADR | NONH for all modes of transport |
WGK Germany | WGK 3 |
Purity | ≥97% |
mp | 213 °C (dec.) (lit.) |
Storage Temp. | −20°C |
UNSPSC | 12161501 |