Toremifene citrate salt

SIGMA/T7204 - ≥98% (HPLC)

Synonym: (Z)-2-(4-(4-Chloro-1,2-diphenyl-1-butenyl)phenoxy)-N,N-dimethylethanamine; Acapodene; Fareston; GTx 006; Z-Toremifene

CAS Number: 89778-27-8
Empirical Formula (Hill Notation): C₂₆H₂₈ClNO · C₆H₈O₇
Molecular Weight: 598.08
MDL Number: MFCD01729016
Linear Formula: C₂₆H₂₈ClNO · C₆H₈O₇
Product Type: Chemical

Catalog Number	PKG Qty.	Price


45-T7204-5MG	5 mg	$71.80 1/EA	Add To Favorites
45-T7204-25MG	25 mg	$290.00 1/EA	Add To Favorites

Properties
Descriptions
Safety Info.
Basic Data

assay	≥98% (HPLC)
color	white to off-white
form	powder
InChI	1S/C26H28ClNO.C6H8O7/c1-28(2)19-20-29-24-15-13-23(14-16-24)26(22-11-7-4-8-12-22)25(17-18-27)21-9-5-3-6-10-21;7-3(8)1-6(13,5(11)12)2-4(9)10/h3-16H,17-20H2,1-2H3;13H,1-2H2,(H,7,8)(H,9,10)(H,11,12)/b26-25-;
InChI key	IWEQQRMGNVVKQW-OQKDUQJOSA-N
Quality Level	100
SMILES string	OC(=O)CC(O)(CC(O)=O)C(O)=O.CN(C)CCOc1ccc(cc1)C(=C(CCCl)c2ccccc2)c3ccccc3
solubility	DMSO: >10 mg/mL
storage condition	desiccated
storage temp.	2-8°C

Application:	Toremifene citrate salt has been used: • in cell-based ELISA • as a positive control to detect its antiviral activity against Ebola virus (EBOV) • to treat MCF7 and T47D breast cancer cell lines
Biochem/physiol Actions:	Toremifene citrate is an oral selective estrogen receptor modulator (SERM). It is used in advanced (metastatic) breast cancer and being evaluated for prevention of prostate cancer. Toremifene citrate is known to increase bone mineral density in prostate cancer patients undergoing androgen deprivation therapy†.
Features and Benefits:	This compound is featured on the Nuclear Receptors (Steroids) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here .
General description:	Toremifene is a triphenylethylene derivative. It exhibits antitumor and antiestrogen effects. Toremifene has estrogen-agonist effects on blood lipids and endometrium.
Packaging:	5, 25 mg in glass bottle
Preparation Note:	Toremifene citrate salt is soluble in DMSO at a concentration that is greater than 10 mg/ml.

Symbol	GHS05,GHS07,GHS09
Signal word	Danger
Hazard statements	H302 - H318 - H410
Precautionary statements	P273 - P280 - P301 + P312 + P330 - P305 + P351 + P338 + P310
Hazard Codes	Xn,N
Risk Statements	22-41-50/53
Safety Statements	26-39-60-61
RIDADR	UN 3077 9 / PGIII
WGK Germany	WGK 3
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable

Purity	≥98% (HPLC)
Storage Temp.	2-8°C
UNSPSC	51111800

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