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Teijin compound 1 hydrochloride

SIGMA/T7330 - ≥98% (HPLC), powder

Synonym: N-[2-[[(3R)-1-[(4-chlorophenyl)methyl]-3-pyrrolidinyl]amino]-2-oxoethyl]-3-(trifluoromethyl)benzamide hydrochloride

Empirical Formula (Hill Notation): C21H21ClF3N3O2·HCl
Molecular Weight: 476.32
MDL Number: MFCD16618399
Linear Formula: C21H21ClF3N3O2·HCl
Product Type: Chemical

Catalog Number PKG Qty. Price Quantity
45-T7330-5MG 5 mg
$0.00
1/EA
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45-T7330-25MG 25 mg
$620.00
1/EA
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assay ≥98% (HPLC)
color white to tan
form powder
InChI 1S/C21H21ClF3N3O2.ClH/c22-17-6-4-14(5-7-17)12-28-9-8-18(13-28)27-19(29)11-26-20(30)15-2-1-3-16(10-15)21(23,24)25;/h1-7,10,18H,8-9,11-13H2,(H,26,30)(H,27,29);1H/t18-;/m1./s1
InChI key PGUQBBISBKGQDC-GMUIIQOCSA-N
Quality Level 100 
SMILES string Cl.FC(F)(F)c1cccc(c1)C(=O)NCC(=O)N[C@@H]2CCN(C2)Cc3ccc(Cl)cc3
solubility DMSO: ≥20 mg/mL
storage temp. 2-8°C
Application: Studies have reported that Trp982.60, Thr2927.40, His1213.33 and Ile2636.55 of Teijin compound 1 significantly affect the antagonistic functions of the compound at CCR2.
Biochem/physiol Actions: Teijin compound 1 is CCR2b receptor antagonist. Teijin compound 1 inhibits cell chemotaxis induced by MCP-1. The chemokine receptors CCR2 is G protein-coupled receptors (GPCR), and is mainly expressed in monocytes, immature dendritic cells, activated T-lymphocytes and basophils.
Packaging: 5, 25 mg in glass bottle
Preparation Note: Teijin compound 1 hydrochloride is soluble in DMSO at a concentration that is greater than or equal to 20 mg/ml.
RIDADR NONH for all modes of transport
WGK Germany WGK 3
Flash Point(F) Not applicable
Flash Point(C) Not applicable
Purity ≥98% (HPLC)
Storage Temp. 2-8°C
UNSPSC 51111800

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