Tetracaine
SIGMA/T7383 - ≥98% (TLC)
Synonym: 4-
CAS Number: 94-24-6
Empirical Formula (Hill Notation): C15H24N2O2
Molecular Weight: 264.36
EC Number: 202-316-6
MDL Number: MFCD00053787
Linear Formula: C15H24N2O2
Product Type: Chemical
This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material. This image depicts SKU: T7383-25G
This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material. This image depicts SKU: T7383-100G
| assay | ≥98% (TLC) |
| biological source | synthetic (organic) |
| form | powder |
| InChI | 1S/C15H24N2O2/c1-4-5-10-1 |
| InChI key | GKCBAIGFKIBETG-UHFFFAOYSA |
| Quality Level | 200  |
| SMILES string | CCCCNc1ccc(cc1)C(=O)OCCN( |
| storage temp. | 2-8°C |
| technique(s) | toxicology assay: suitable |
| Application: | Tetracaine can be used as a research tool for studying E-C coupling in both skeletal as well as cardiac muscle. The product is a local anaesthetic drug used for studying the impact of numerous drugs on Tumour-necrosis-factor (TNF)-mediated cytotoxicity as well as TNF-induced arachidonic acid release. |
| Application: | Tetracaine has been used as an anesthetic and to lower the glucose synthesis in upper small intestinal infusions. It has also been used to inhibit ryanodine receptors (RyRs) in rats. |
| Application: | Topical ophthalmic anesthetic; used for spinal anesthesia |
| Biochem/physiol Actions: | Blocks voltage-sensitive release of Ca2+ from sarcoplasmic reticulum. |
| Biochem/physiol Actions: | Tetracaine also refers as 4-(Butylamino)benzoic acid 2-(dimethylamino)ethyl ester interfere with calcium movement in muscle and non-muscle cells and can inhibit potassium-induced as well as caffeine-induced shortening of outer hair cells (OHC′s). But, the product can′t inhibit electrically-induced shortening of OHC′s.The product can also stimulate caspase activation and inhibits pro-survival signalling pathways which in turn induce human renal cell apoptosis. |
| Biochem/physiol Actions: | Tetracaine blocks intracellular sodium channels. It mediates phosphorylation of eukaryotic initiation factor 2 (eIF2 α) via translational inhibition of P-body formation. |
| General description: | Tetracaine belongs to the amino-ester class and has a pKa of 8.46. |
| Packaging: | 25, 100 g in poly bottle |
| Preparation Note: | 250 mg of tetracaine dissolves in 5 ml of EtOH to yield a clear, colorless solution. The product is also soluble in chloroform and ether at a ratio of 1:2 and in ethanol at 1:5. It is very slightly soluble in water. |
| Symbol |   GHS06,GHS08 |
| Signal word | Danger |
| Hazard statements | H301 - H317 - H351 |
| Precautionary statements | P201 - P280 - P301 + P310 + P330 - P302 + P352 |
| Hazard Codes | Xn |
| Risk Statements | 22-40-42/43 |
| Safety Statements | 22-36/37 |
| RIDADR | UN 2811 6.1 / PGIII |
| WGK Germany | WGK 3 |
| Purity | ≥98% (TLC) |
| Storage Temp. | 2-8°C |
| UNSPSC | 12352200 |