TN-16

SIGMA/T7580 - ≥98% (HPLC)

Synonym: 3-[1-(Phenylamino)ethylidene]-5-(phenylmethyl)-2,4-pyrrolidinedione; NSC 239274

CAS Number: 33016-12-5
Empirical Formula (Hill Notation): C₁₉H₁₈N₂O₂
Molecular Weight: 306.36
Linear Formula: C₁₉H₁₈N₂O₂
Product Type: Chemical

Catalog Number	PKG Qty.	Price	Quantity


45-T7580-5MG	5 mg	$146.00 1/EA		Add To Favorites
45-T7580-25MG	25 mg	$455.00 1/EA		Add To Favorites

Properties
Descriptions
Safety Info.
Basic Data

assay	≥98% (HPLC)
color	white to tan
form	powder
InChI	1S/C19H18N2O2/c1-13(20-15-10-6-3-7-11-15)17-18(22)16(21-19(17)23)12-14-8-4-2-5-9-14/h2-11,16,20H,12H2,1H3,(H,21,23)/b17-13-
InChI key	KWSXUGYAGMSUTN-LGMDPLHJSA-N
Quality Level	100
SMILES string	CC(Nc1ccccc1)=C2C(=O)NC(Cc3ccccc3)C2=O
solubility	DMSO: ≥17 mg/mL
storage temp.	2-8°C

Application:	TN-16 has been used as a microtubule disrupting agent to study its effect on autophagic process in human and mouse mammary carcinoma cell lines .
Biochem/physiol Actions:	3-(l-anilinoethylidene)-5-benzylpyrrolidine-2,4-dione (TN-16), a tenuazonic acid derivative, is a synthetic antitumor agent which arrests mitosis of tumor cells at metaphase. It is a colchicine site binding agent and a powerful autophagy flux inhibitor that could be used as a conventional autophagy inhibitor with anti-cancer potential in pre-clinical trials.
Biochem/physiol Actions:	Inhibitor of microtubule assembly
Biochem/physiol Actions:	TN-16 is a synthetic compound that blocks the assembly, and promotes the dissociation of microtubules. It can prevent the b-TrCP-mediated degradation of the transcription factor Gli2, leading to the up-regulation of BMP-2 and supporting a role for microtubule formation in the regulation of bone formation.
Packaging:	5, 25 mg in glass bottle

Symbol	GHS07,GHS09
Signal word	Warning
Hazard statements	H317 - H400
Precautionary statements	P273 - P280 - P302 + P352
Hazard Codes	Xi,N
Risk Statements	43-50/53
Safety Statements	36/37-60-61
RIDADR	UN 3077 9 / PGIII
WGK Germany	WGK 3
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable

Purity	≥98% (HPLC)
Storage Temp.	2-8°C
UNSPSC	51111800

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