TN-16
SIGMA/T7580 - ≥98% (HPLC)
Synonym: 3-
CAS Number: 33016-12-5
Empirical Formula (Hill Notation): C19H18N2O2
Molecular Weight: 306.36
Linear Formula: C19H18N2O2
Product Type: Chemical
assay | ≥98% (HPLC) |
color | white to tan |
form | powder |
InChI | 1S/C19H18N2O2/c1-13(20-15 |
InChI key | KWSXUGYAGMSUTN-LGMDPLHJSA |
Quality Level | 100 ![]() |
SMILES string | CC(Nc1ccccc1)=C2C(=O)NC |
solubility | DMSO: ≥17 mg/mL |
storage temp. | 2-8°C |
Application: | TN-16 has been used as a microtubule disrupting agent to study its effect on autophagic process in human and mouse mammary carcinoma cell lines . |
Biochem/physiol Actions: | 3-(l-anilinoethylidene)-5 |
Biochem/physiol Actions: | Inhibitor of microtubule assembly |
Biochem/physiol Actions: | TN-16 is a synthetic compound that blocks the assembly, and promotes the dissociation of microtubules. It can prevent the b-TrCP-mediated degradation of the transcription factor Gli2, leading to the up-regulation of BMP-2 and supporting a role for microtubule formation in the regulation of bone formation. |
Packaging: | 5, 25 mg in glass bottle |
Symbol | ![]() ![]() |
Signal word | Warning |
Hazard statements | H317 - H400 |
Precautionary statements | P273 - P280 - P302 + P352 |
Hazard Codes | Xi,N |
Risk Statements | 43-50/53 |
Safety Statements | 36/37-60-61 |
RIDADR | UN 3077 9 / PGIII |
WGK Germany | WGK 3 |
Flash Point(F) | Not applicable |
Flash Point(C) | Not applicable |
Purity | ≥98% (HPLC) |
Storage Temp. | 2-8°C |
UNSPSC | 51111800 |