TFLLR-NH2 trifluoroacetate salt
SIGMA/T7830 - >98% (HPLC)
Synonym: L-
Empirical Formula (Hill Notation): C31H53N9O6 · xC2HF3O2
Molecular Weight: 647.81 (free base basis)
MDL Number: MFCD05663482
Linear Formula: C31H53N9O6 · xC2HF3O2
Product Type: Chemical
assay | >98% (HPLC) |
color | white to tan |
form | lyophilized powder |
InChI | 1S/C31H53N9O6.C2HF3O2/c1- |
InChI key | QVNWOGSDGQDGHP-MKVNCOEFSA |
Quality Level | 100 ![]() |
SMILES string | OC(=O)C(F)(F)F.CC(C)C[C@H |
solubility | H2O: >2 mg/mL |
storage temp. | −20°C |
Amino Acid Sequence: | Thr-Phe-Leu-Leu-Arg-NH2 |
Application: | TFLLR-NH2 trifluoroacetate salt has been used as a protease-activated receptor-1 (PAR-1) agonist to study its effects on hippocampal CA1 pyramidal neurons and Swell1 knock out mice (cKO). |
Biochem/physiol Actions: | TFLLR-NH2 is a protease-activated receptor (PARs) agonist which is more selective to PAR-1 than SFLLRN-NH2. Protease-activated receptors (PARs) are present on various organs including, plateles, mast cell, gallblader, oesophagus etc, and regulate various physiological processes including human platelet aggregation, vascular contraction/relaxation, and an increase in endothelial permeability. Recent papers indicated that PAR′s are also involved in sensory processing. Specificly PAR ligands enhance glutamatergic excitatory transmission in substantia gelatinosa (SG) neurons of adult rat spinal cord slices. |
Packaging: | 5, 25 mg in glass bottle |
Preparation Note: | TFLLR-NH2 trifluoroacetate is soluble in water at a concentration that is greater than 2 mg/ml. |
RIDADR | NONH for all modes of transport |
WGK Germany | WGK 3 |
Flash Point(F) | Not applicable |
Flash Point(C) | Not applicable |
Purity | >98% (HPLC) |
Storage Temp. | −20°C |
UNSPSC | 12352200 |