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TFLLR-NH2 trifluoroacetate salt

SIGMA/T7830 - >98% (HPLC)

Synonym: L-Threonyl-L-phenylalanyl-L-leucyl-L-leucyl- L-argininamide trifluoroacetate salt; Thr-Phe-Leu-Leu-Arg-NH2 trifluoroacetate salt

Empirical Formula (Hill Notation): C31H53N9O6 · xC2HF3O2
Molecular Weight: 647.81 (free base basis)
MDL Number: MFCD05663482
Linear Formula: C31H53N9O6 · xC2HF3O2
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-T7830-5MG 5 mg
 $147.00
1/EA		 Add To Favorites
45-T7830-25MG 25 mg
 $581.00
1/EA		 Add To Favorites

 

assay >98% (HPLC)
color white to tan
form lyophilized powder
InChI 1S/C31H53N9O6.C2HF3O2/c1-17(2)14-22(27(43)37-21(26(33)42)12-9-13-36-31(34)35)38-28(44)23(15-18(3)4)39-29(45)24(16-20-10-7-6-8-11-20)40-30(46)25(32)19(5)41;3-2(4,5)1(6)7/h6-8,10-11,17-19,21-25,41H,9,12-16,32H2,1-5H3,(H2,33,42)(H,37,43)(H,38,44)(H,39,45)(H,40,46)(H4,34,35,36);(H,6,7)/t19-,21+,22+,23+,24+,25+;/m1./s1
InChI key QVNWOGSDGQDGHP-MKVNCOEFSA-N
Quality Level 100 
SMILES string OC(=O)C(F)(F)F.CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](N)[C@@H](C)O)C(=O)N[C@@H](CCCNC(N)=N)C(N)=O
solubility H2O: >2 mg/mL
storage temp. −20°C
Amino Acid Sequence: Thr-Phe-Leu-Leu-Arg-NH2
Application: TFLLR-NH2 trifluoroacetate salt has been used as a protease-activated receptor-1 (PAR-1) agonist to study its effects on hippocampal CA1 pyramidal neurons and Swell1 knock out mice (cKO).
Biochem/physiol Actions: TFLLR-NH2 is a protease-activated receptor (PARs) agonist which is more selective to PAR-1 than SFLLRN-NH2. Protease-activated receptors (PARs) are present on various organs including, plateles, mast cell, gallblader, oesophagus etc, and regulate various physiological processes including human platelet aggregation, vascular contraction/relaxation, and an increase in endothelial permeability. Recent papers indicated that PAR′s are also involved in sensory processing. Specificly PAR ligands enhance glutamatergic excitatory transmission in substantia gelatinosa (SG) neurons of adult rat spinal cord slices.
Packaging: 5, 25 mg in glass bottle
Preparation Note: TFLLR-NH2 trifluoroacetate is soluble in water at a concentration that is greater than 2 mg/ml.
RIDADR NONH for all modes of transport
WGK Germany WGK 3
Flash Point(F) Not applicable
Flash Point(C) Not applicable
Purity >98% (HPLC)
Storage Temp. −20°C
UNSPSC 12352200

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