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Trimethoprim

SIGMA/T7883 - ≥98.5%

Synonym: 2,4-Diamino-5-(3,4,5-trimethoxybenzyl)pyrimidine; NSC 106568

CAS Number: 738-70-5
Empirical Formula (Hill Notation): C14H18N4O3
Molecular Weight: 290.32
EC Number: 212-006-2
MDL Number: MFCD00036761
Linear Formula: C14H18N4O3
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-T7883-5G 5 g
 $139.00
1/EA		 Add To Favorites
45-T7883-25G 25 g
 $472.00
1/EA		 Add To Favorites
45-T7883-100G 100 g
 $1330.00
1/EA		 Add To Favorites

 

antibiotic activity spectrum Gram-negative bacteria
  Gram-positive bacteria
  mycobacteria
assay ≥98.5%
color white to light yellow
form powder
InChI 1S/C14H18N4O3/c1-19-10-5-8(6-11(20-2)12(10)21-3)4-9-7-17-14(16)18-13(9)15/h5-7H,4H2,1-3H3,(H4,15,16,17,18)
InChI key IEDVJHCEMCRBQM-UHFFFAOYSA-N
mode of action DNA synthesis | interferes
  enzyme | inhibits
Quality Level 200 
SMILES string COc1cc(Cc2cnc(N)nc2N)cc(OC)c1OC
solubility DMSO: soluble
storage condition (Keep container tightly closed in a dry and well-ventilated place. Keep in a dry place.)
storage temp. 2-8°C
Application: Primarily used as an antibacterial agent. Dihydrofolate reductase inhibitor with selectivity for the prokaryote enzyme.
Application: Trimethoprim is primarily used as an antibacterial agent. It has dihydrofolate reductase inhibitor activity with selectivity for the prokaryote enzyme. It is used to treat urinary tract infections, mild acute prostatitis, recurrent cystitis, asymptomatic bacteriuria during pregnancy and respiratory tract infections.
Biochem/physiol Actions: The combination of trimethoprim and sulfamethoxazole interferes with the cellular metabolism of folic acid in the bacterial cell by blocking the biosynthesis of nucleotides. Trimethoprim binds to dihydrofolate reductase and inhibits the reduction of dihydrofolic acid (DHF) to tetrahydrofolic acid (THF). THF is an essential precursor in the thymidine synthesis pathway and interference with this pathway inhibits bacterial DNA synthesis.
General description: Chemical structure: pyrimidine
Other Notes: Keep container tightly closed in a dry and well-ventilated place. Keep in a dry place.
Packaging: 5G,25G,100G
Purity ≥98.5%
Storage Temp. 2-8°C
UNSPSC 51101500

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