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(R)-Tomoxetine hydrochloride

SIGMA/T7947 - solid

Synonym: (R)-N-Methyl-γ-(2-methyl­phenoxy)benzenepropanamine hydrochloride; Atomoxetine hydrochloride

CAS Number: 82248-59-7
Empirical Formula (Hill Notation): C17H21NO · HCl
Molecular Weight: 291.82
MDL Number: MFCD06410992
Linear Formula: C17H21NO · HCl
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-T7947-25MG 25 mg
 $594.00
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45-T7947-100MG 100 mg
 $1500.00
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This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material. This image depicts SKU: T7947-25MG

 

form solid
InChI 1S/C17H21NO.ClH/c1-14-8-6-7-11-16(14)19-17(12-13-18-2)15-9-4-3-5-10-15;/h3-11,17-18H,12-13H2,1-2H3;1H/t17-;/m1./s1
InChI key LUCXVPAZUDVVBT-UNTBIKODSA-N
originator Eli Lilly
Quality Level 100 
SMILES string CNCC[C@@H](OC1=CC=CC=C1C)C2=CC=CC=C2.[H]Cl
storage temp. 2-8°C
Application: (R)-Tomoxetine hydrochloride has been used as a noradrenaline reuptake inhibitor:
• to study the role of L-threo-3,4-dihydroxyphenylserine (L-DOPS) in the pathogenesis of Alzheimer′s disease in mice
• to study its effects on set shifting in rats
• to study its effects on rat brain as a result of its long-term use
Biochem/physiol Actions: (R)-Tomoxetine hydrochloride is an efficient inhibitor of presynaptic norepinephrine transporters. It also positively regulates the release of acetylcholine in the prefrontal cortex (PFC). (R)-Tomoxetine hydrochloride binds to the serotonin (5-HT) transporter. It is involved in blocking the cortical N-methyl-D-aspartate (NMDA) receptors.. (R)-Tomoxetine hydrochloride exhibits therapeutic effects against attention-deficit/hyperactivity disorder (ADHD) and comorbid oppositional defiant disorder (ODD).
Biochem/physiol Actions: Norepinephrine uptake blocker.
Features and Benefits: This compound is featured on the Biogenic Amine Transporters  page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here .
Features and Benefits: This compound was developed by Eli Lilly . To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here .
Packaging: 25, 50, 100 mg in glass bottle
RIDADR NONH for all modes of transport
WGK Germany WGK 3
Flash Point(F) Not applicable
Flash Point(C) Not applicable
Storage Temp. 2-8°C
UNSPSC 12352200

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