Tau Protein Ladder, 6 isoforms human
SIGMA/T7951 - recombinant, expressed in E. coli, ≥90% (SDS-PAGE), buffered aqueous glycerol solution
Synonym: Tau Protein Ladder
MDL Number: MFCD09265460
Product Type: Chemical
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| assay | ≥90% (SDS-PAGE) |
| biological source | human |
| composition | dodecyl sulphate sodium salt, 1-5% |
| glycerine, 20-30% | |
| mercaptoethanol, 10-20% | |
| form | buffered aqueous glycerol solution |
| mol wt | 36800 |
| 39700 | |
| 40000 | |
| 42600 | |
| 42900 | |
| 45900 | |
| Quality Level | 200  |
| recombinant | expressed in E. coli |
| shipped in | dry ice |
| storage temp. | −20°C |
| technique(s) | immunoelectrophoresis: 10-20 μL using recombinant Tau protein marker |
| western blot: 2-5 μL using recombinant Tau protein marker | |
| UniProt accession no. | P10636  |
| Application: | Tau Protein Ladder, 6 isoforms human has been used as a sample in immunomagnetic reduction (IMR) assay. It has also been used as positive control in western blotting. |
| Biochem/physiol Actions: | In neurons, tau protein plays an important role in maintaining microtubule assembly and stability. It acts as a connector between microtubules and other cytoskeletal elements or proteins. Overexpression of the protein has been observed in Alzheimer′s disease and various neurodegenerative disorders denoted as ‘tauopathies′. Thus, pathological tau proteins act as a potential biomarker in the neurodegenerative process. |
| Features and Benefits: | Contains 6 recombinant Tau proteins expressed in E. coli, which comprise six Tau isoforms with molecular weights of 45,900, 42,600, 42,900, 39,700, 40,000, and 36,800 respectively. No histidine-tags are present in the proteins. |
| General description: | Research area: Neuroscience Tau gene, spanning 100 kb with 16 exons, is mapped to human chromosome 17q21. The six alternative splice variants of protein ranging in size from 352-441 amino acids have been identified in human adult brain. Tau is a member of the microtubule-associated protein (MAP) family. It is predominantly expressed in neurons. |
| Packaging: | A 50 μL vial of Tau Protein Ladder contains 0.25 μg of each of the six isoforms. |
| Physical form: | Solution in 125 mM Tris-HCl, pH 6.8, containing 4% SDS, 10% 2-mercaptoethanol, 20% glycerol, and 0.004% bromphenol blue. |
| Preparation Note: | Tightly closed. Keep in a well-ventilated place. Keep locked up or in an area accessible only to qualified or authorized persons |
| Symbol |    GHS05,GHS06,GHS08 |
| Signal word | Danger |
| Hazard statements | H302 - H311 - H315 - H317 - H318 - H361d - H373 - H412 |
| Precautionary statements | P273 - P280 - P301 + P312 - P302 + P352 + P312 - P305 + P351 + P338 - P308 + P313 |
| Hazard Codes | Xn,N |
| Risk Statements | 20/21/22-41-43-48/22-51/53 |
| Safety Statements | 26-36/37/39-61 |
| RIDADR | UN 3082 9 / PGIII |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Purity | ≥90% (SDS-PAGE) |
| Storage Temp. | −20°C |
| UNSPSC | 12352202 |