Tofisopam
SIGMA/T8200 - ≥98% (HPLC), solid
Synonym: 7,8-
CAS Number: 22345-47-7
Empirical Formula (Hill Notation): C22H26N2O4
Molecular Weight: 382.45
EC Number: 244-922-3
MDL Number: MFCD00823171
Linear Formula: C22H26N2O4
Product Type: Chemical
assay | ≥98% (HPLC) |
color | white |
drug control | regulated under CDSA - not available from Sigma-Aldrich Canada |
form | solid |
InChI | 1S/C22H26N2O4/c1-7-15-13( |
InChI key | RUJBDQSFYCKFAA-UHFFFAOYSA |
Quality Level | 100 ![]() |
SMILES string | CCC1C(C)=NN=C(c2ccc(OC)c( |
solubility | DMSO: ~14 mg/mL |
H2O: insoluble |
Application: | Tofisopam has been used for studying its biochemical mechanisms of actions using drug repositioning strategies. |
Biochem/physiol Actions: | Ligand for the GABAA receptor benzodiazepine modulatory site. |
Biochem/physiol Actions: | Studies have reported that tofisopam functions by blocking PDE4 (phosphodiesterase 4). Furthermore, the S-enantiomer of tofisopam is considered ten times more active than R-enantiomer. |
Packaging: | 10, 50 mg in glass bottle |
Preparation Note: | Tofisopam is soluble in DMSO at approximately 14 mg/ml. However, it is insoluble in water. |
Symbol | ![]() ![]() |
Signal word | Warning |
Hazard statements | H302 - H400 |
Precautionary statements | P273 - P301 + P312 + P330 |
Hazard Codes | Xn,N |
Risk Statements | 22-50 |
Safety Statements | 60-61 |
RIDADR | UN 3077 9 / PGIII |
WGK Germany | WGK 2 |
Flash Point(F) | Not applicable |
Flash Point(C) | Not applicable |
Purity | ≥98% (HPLC) |
UNSPSC | 12352200 |