Anti-TRPC1 antibody produced in rabbit
SIGMA/T8276 - affinity isolated antibody, lyophilized powder
Synonym: Trpc1 Antibody; Trpc1 Antibody - Anti-TRPC1 antibody produced in rabbit; Anti-Transient receptor potential cation channel, subfamily C, member 1
MDL Number: MFCD02686004
Product Type: Chemical
Immunohistochemistry Anti-TRPC1: Cat. No. T8276: Immunohistochemical staining of Mouse cerebellum frozen sections using Anti-TRPC1 antibody. A. TRPC1 (red) appears in Purkinje cells (arrows) and in the molecular (Mol) and granule (Gran) layers. B. Staining with Mouse Anti-Parvalbumin (PV) in the same brain section. C. Confocal merge of TRPC1 and PV demonstrates partial co-localization in the Purkinje and the molecular layers.
Immunoblotting Anti-TRPC1: Cat. No. T8276: Western blot analysis of Rat brain membranes. Lanes 1. Anti-TRPC1 antibody, (1:200). 2. Anti-TRPC1 antibody, preincubated with the control peptide antigen.
| antibody form | affinity isolated antibody |
| antibody product type | primary antibodies |
| biological source | rabbit |
| clone | polyclonal |
| conjugate | unconjugated |
| form | lyophilized powder |
| Quality Level | 100  |
| species reactivity | rat |
| storage temp. | −20°C |
| technique(s) | immunohistochemistry: suitable |
| western blot (chemiluminescent): suitable | |
| UniProt accession no. | Q9QX01  |
| Biochem/physiol Actions: | Transient receptor potential cation channel subfamily C member 1 (TRPC1) facilitates Ca2+ entry upon store depletion in a variety of cell types by forming a multimeric complex with other TRPCs. The encoded protein is implicated in the odontoblast-like differentiation of human dental pulp cells (hDPCs). Mutation in the gene is associated with the development type 2 diabetes mellitus (T2D). Decreased expression of the gene leads to hepatocellular carcinoma cell proliferation and thus, TRPC1 can be considered as a potential therapeutic target for hepatocellular carcinoma. |
| Disclaimer: | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
| General description: | Transient receptor potential cation channel subfamily C member 1 (TRPC1) is encoded by the gene mapped to human chromosome 3q22-24. The encoded protein is a member of the transient receptor potential (TRP) superfamily of cation channels and is distributed in both glomeruli and glomerular mesangial cells. |
| Immunogen: | Synthetic protein corresponding to amino acids 557-571 of human TRPC1 (GenBank® Accession No. P48995). The epitope is identical in mouse and rat and highly homologous in bovine and Xenopus. |
| Legal Information: | GenBank is a registered trademark of United States Department of Health and Human Services |
| Physical form: | Lyophilized at 0.3 mg/ml from phosphate buffered saline, pH 7.4, containing 1% bovine serum albumin and 0.05% sodium azide. |
| Symbol |   GHS06,GHS09 |
| Signal word | Danger |
| Hazard statements | H301 + H311 - H411 |
| Precautionary statements | P273 - P280 - P301 + P310 + P330 - P302 + P352 + P312 - P391 - P501 |
| Hazard Codes | T,N |
| Risk Statements | 24/25-51/53 |
| Safety Statements | 36/37-45-61 |
| RIDADR | UN 3172 6.1 / PGIII |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Supplemental Hazard Statements | EUH032 |
| Storage Temp. | −20°C |
| UNSPSC | 12352203 |