Tertiapin
SIGMA/T8316 - >95%
CAS Number: 403843-29-8
Empirical Formula (Hill Notation): C106H176N34O23S5
Molecular Weight: 2455.07
MDL Number: MFCD02094633
Linear Formula: C106H176N34O23S5
Product Type: Chemical
| assay | >95% |
| form | powder |
| Quality Level | 200  |
| storage temp. | −20°C |
| technique(s) | HPLC: suitable |
| Amino Acid Sequence: | Ala-Leu-Cys-Asn-Cys-Asn-A |
| Application: | Tertiapin was used for developing a novel CZE-DAD method for analyzing the honeybee venom. |
| Biochem/physiol Actions: | A potent inhibitor of the inward-rectifier K+ channels, blocked a G-protein-gated channel (GIRK1/4) and the ROMK1 channel with nanomolar affinities, however a closely related channel, IRK1, was insensitive to tertiapin. Thus, tertiapin is a tool for purifying functional channels as well as for screening pharmaceutical agents against these channels. |
| Biochem/physiol Actions: | Tertiapin is a peptide isolated from honey bee venom, which is a selective IKACh blocker that prolongs the atrial effective refractory period and terminates the atrial fibrillation. It is a selective and potent inhibitor of muscarinic K+ channels in rabbit cardiac myocytes. |
| Preparation Note: | Tertiapin dissolves in water at 1 mg/ml to yield a clear solution. |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Purity | >95% |
| Storage Temp. | −20°C |
| UNSPSC | 12352200 |