Trifluoperazine dihydrochloride
SIGMA/T8516 - ≥99%, powder
Synonym: 10-
CAS Number: 440-17-5
Empirical Formula (Hill Notation): C21H24F3N3S · 2HCl
Molecular Weight: 480.42
EC Number: 207-123-0
MDL Number: MFCD00012656
Linear Formula: C21H24F3N3S · 2HCl
Product Type: Chemical
assay | ≥99% |
color | white to off-white |
form | powder |
InChI | 1S/C21H24F3N3S.2ClH/c1-25 |
InChI key | BXDAOUXDMHXPDI-UHFFFAOYSA |
mp | 243 °C (dec.) (lit.) |
Quality Level | 100 ![]() |
SMILES string | Cl[H].Cl[H].CN1CCN(CCCN2c |
solubility | DMSO: soluble |
ethanol: soluble 5 mg/mL | |
H2O: soluble 50 mg/mL, clear, colorless to yellow | |
storage temp. | −20°C |
Application: | Trifluoperazine dihydrochloride has been used as a calmodulin kinase antagonist in cultured Aplysia californica neurons. Trifluoperazine dihydrochloride has also been used as a PMCA inhibitor in mouse duodenal tissues to block the transcellular active calcium flux. |
Application: | Trifluoperazine dihydrochloride has been used: • to inhibit clathrin-dependent endocytosis • as a calmodulin kinase antagonist in cultured Aplysia californica neurons • as a plasma membrane Ca2+-ATPase (PMCA) inhibitor in mouse duodenal tissues to block the transcellular active calcium flux |
Biochem/physiol Actions: | Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels. |
Biochem/physiol Actions: | Trifluoperazine dihydrochloride is useful in treating schizophrenia, disturbed behavior, severe anxiety, nausea and vomiting. |
Features and Benefits: | This compound is featured on the Potassium Channels ![]() ![]() |
Packaging: | 5, 10 g in glass bottle |
Preparation Note: | Trifluoperazine dihydrochloride dissolves in water at 50 mg/ml, with heat as required, and yields a clear, colorless to yellow solution. It is also soluble in DMSO and ethanol (5 mg/ml). |
Symbol | ![]() ![]() ![]() |
Signal word | Danger |
Hazard statements | H302 - H319 - H336 - H341 - H372 - H410 |
Precautionary statements | P201 - P273 - P301 + P312 + P330 - P305 + P351 + P338 - P308 + P313 |
Hazard Codes | Xn |
Risk Statements | 22 |
Safety Statements | 36 |
RIDADR | NONH for all modes of transport |
WGK Germany | WGK 3 |
Flash Point(F) | Not applicable |
Flash Point(C) | Not applicable |
Purity | ≥99% |
mp | 243 °C (dec.) (lit.) |
Storage Temp. | −20°C |
UNSPSC | 12352200 |