Trifluoperazine dihydrochloride
SIGMA/T8516 - ≥99%, powder
Synonym: 10-
CAS Number: 440-17-5
Empirical Formula (Hill Notation): C21H24F3N3S · 2HCl
Molecular Weight: 480.42
EC Number: 207-123-0
MDL Number: MFCD00012656
Linear Formula: C21H24F3N3S · 2HCl
Product Type: Chemical
This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material. This image depicts SKU: T8516-5G
| assay | ≥99% |
| color | white to off-white |
| form | powder |
| InChI | 1S/C21H24F3N3S.2ClH/c1-25 |
| InChI key | BXDAOUXDMHXPDI-UHFFFAOYSA |
| mp | 243 °C (dec.) (lit.) |
| Quality Level | 100  |
| SMILES string | Cl[H].Cl[H].CN1CCN(CCCN2c |
| solubility | DMSO: soluble |
| ethanol: soluble 5 mg/mL | |
| H2O: soluble 50 mg/mL, clear, colorless to yellow | |
| storage temp. | −20°C |
| Application: | Trifluoperazine dihydrochloride has been used as a calmodulin kinase antagonist in cultured Aplysia californica neurons. Trifluoperazine dihydrochloride has also been used as a PMCA inhibitor in mouse duodenal tissues to block the transcellular active calcium flux. |
| Application: | Trifluoperazine dihydrochloride has been used: • to inhibit clathrin-dependent endocytosis • as a calmodulin kinase antagonist in cultured Aplysia californica neurons • as a plasma membrane Ca2+-ATPase (PMCA) inhibitor in mouse duodenal tissues to block the transcellular active calcium flux |
| Biochem/physiol Actions: | Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels. |
| Biochem/physiol Actions: | Trifluoperazine dihydrochloride is useful in treating schizophrenia, disturbed behavior, severe anxiety, nausea and vomiting. |
| Features and Benefits: | This compound is featured on the Potassium Channels page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here . |
| Packaging: | 5, 10 g in glass bottle |
| Preparation Note: | Trifluoperazine dihydrochloride dissolves in water at 50 mg/ml, with heat as required, and yields a clear, colorless to yellow solution. It is also soluble in DMSO and ethanol (5 mg/ml). |
| Symbol |    GHS07,GHS08,GHS09 |
| Signal word | Danger |
| Hazard statements | H302 - H319 - H336 - H341 - H372 - H410 |
| Precautionary statements | P201 - P273 - P301 + P312 + P330 - P305 + P351 + P338 - P308 + P313 |
| Hazard Codes | Xn |
| Risk Statements | 22 |
| Safety Statements | 36 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Purity | ≥99% |
| mp | 243 °C (dec.) (lit.) |
| Storage Temp. | −20°C |
| UNSPSC | 12352200 |