O-Tricyclo[5.2.1.0^2,6]dec-9-yl dithiocarbonate potassium salt

SIGMA/T8543 - ≥95%, solid

Synonym: D609

CAS Number: 83373-60-8
Empirical Formula (Hill Notation): C₁₁H₁₅KOS₂
Molecular Weight: 266.46
EC Number: 280-379-9
MDL Number: MFCD00171401
Linear Formula: C₁₁H₁₅KOS₂
Product Type: Chemical

Catalog Number	PKG Qty.	Price


45-T8543-5MG	5 mg	$259.00 1/EA	Add To Favorites
45-T8543-25MG	25 mg	$1040.00 1/EA	Add To Favorites

This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material. This image depicts SKU: T8543-25MG

Properties
Descriptions
Safety Info.
Basic Data

assay	≥95%
biological source	synthetic (organic)
color	off-white to yellow
form	solid
InChI	1S/C11H16OS2.K/c13-11(14)12-10-5-6-4-9(10)8-3-1-2-7(6)8;/h6-10H,1-5H2,(H,13,14);/q;+1/p-1/t6-,7?,8?,9-,10?;/m1./s1
InChI key	IGULCCCBGBDZKQ-HJPGVBIPSA-M
Quality Level	200
SMILES string	[K]SC(=S)OC1CC2CC1C3CCCC23
solubility	acetone: easily soluble
	diethyl ether: insoluble
	H₂O: soluble 50 mg/mL, clear to slightly hazy, colorless to faintly yellow
	hydrocarbons: insoluble

Application:	D609 has been used as a phosphatidylcholine-specific phospholipase C (PC-PLC) inhibitor in mouse bone marrow derived monocytes. D609 has also been reported to significantly reduce the elevated levels of phosphatidylethanolamine binding protein 1 (PEBP1) in apolipoprotein E^-/- mice.
Biochem/physiol Actions:	D609 can block the production of diacylglycerol (DAG) in the cell. D609 functions by inhibiting the phospholipase C-mediated hydrolysis of the phosphate bond present in phosphatidylcholine and other glycerophospholipids.
Biochem/physiol Actions:	Phosphatidylcholine-specific phospholipase C (PLC) and HIV-1 inhibitor. Xanthogenate derivative with in vitro anti-tumor activity.
Packaging:	25 mg in poly bottle
Packaging:	5 mg in glass bottle
Preparation Note:	O-Tricyclo[5.2.1.0^2,6]dec-9-yl dithiocarbonate or D609 is soluble in water at 50 mg/ml and yields a clear to slightly hazy, colorless to light yellow solution. It is also soluble in acetone. However, it is insoluble in ether and hydrocarbons. Alcoholic solutions should not be prepared due to the possibility of transesterification. The product is very labile in solution (1.5 days half-life in tissue culture medium) and is readily hydrolyzed below pH 6.0. Hence, solutions should be prepared immediately before use and unused solutions must be discarded. For tissue culture preparations, the media should be buffered to pH 6.0-7.5. HEPES buffer must not be used as it renders this product toxic.

RIDADR	NONH for all modes of transport
WGK Germany	WGK 3
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable

Purity	≥95%
UNSPSC	41106300

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