Trichostatin A

SIGMA/T8552 - ≥98% (HPLC), from Streptomyces sp.

Synonym: TSA; [R-(E,E)]-7-[4-(Dimethylamino)phenyl]-N-hydroxy-4,6-dimethyl-7-oxo-2,4-heptadienamide

CAS Number: 58880-19-6
Empirical Formula (Hill Notation): C₁₇H₂₂N₂O₃
Molecular Weight: 302.37
MDL Number: MFCD03848392
Linear Formula: C₁₇H₂₂N₂O₃
Product Type: Chemical

Catalog Number	PKG Qty.	Price


45-T8552-1MG	1 mg	$195.00 1/EA	Add To Favorites
45-T8552-5MG	5 mg	$632.00 1/EA	Add To Favorites

This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material. This image depicts SKU: T8552-1MG

Properties
Descriptions
Safety Info.
Basic Data

assay	≥98% (HPLC)
biological source	Streptomyces sp.
form	powder
InChI	1S/C17H22N2O3/c1-12(5-10-16(20)18-22)11-13(2)17(21)14-6-8-15(9-7-14)19(3)4/h5-11,13,22H,1-4H3,(H,18,20)/b10-5+,12-11+/t13-/m1/s1
InChI key	RTKIYFITIVXBLE-QEQCGCAPSA-N
Quality Level	300
SMILES string	C[C@H](C=C(C)C=CC(=O)NO)C(=O)c1ccc(cc1)N(C)C
solubility	acetone: slightly soluble
	acetonitrile: soluble
	benzene: slightly soluble
	chloroform: slightly soluble
	DMF: soluble
	DMSO: soluble
	ethanol: soluble
	ethyl acetate: slightly soluble
	H₂O: insoluble
	lower alcohols: soluble
	methanol: soluble 1.90-2.10 mg/mL, clear, colorless to faint yellow or tan
storage temp.	−20°C

Application:	Trichostatin A (TSA) has been used during the production of cloned mouse embryos. TSA has also been used as a histone deacetylase (HDAC) inhibitor in LNCaP human prostate cancer cells, as well as in MON and HeLa cells.
Biochem/physiol Actions:	Trichostatin A (TSA) inhibits histone deacetylase at nanomolar concentrations; resultant histone hyperacetylation leads to chromatin relaxation and modulation of gene expression. May be involved in cell cycle progression of several cell types, inducing cell growth arrest at both G and G/M phases; may induce apoptosis. Enhances the efficacy of anticancer agents that target DNA. Trichostatin A serves as an epigenetic modifier.
Biochem/physiol Actions:	Trichostatin A inhibits histone deacetylase at nanomolar concentrations; resultant histone hyperacetylation leads to chromatin relaxation and modulation of gene expression.
Features and Benefits:	This compound is a featured product for Apoptosis and Gene Regulation research. Discover more featured Apoptosis and Gene Regulation products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm .
General description:	Trichostatin A (TSA) is a potent and specific inhibitor of histone deacetylase (HDAC) activity. It is an antifungal antibiotic with cytostatic and differentiating properties in mammalian cell culture.
Packaging:	1, 5 mg in glass bottle
Preparation Note:	Trichostatin A is soluble in methanol at 1.90 - 2.10 mg/ml and yields a clear, colorless to faint yellow/tan solution. It is also soluble in DMSO, DMF, acetonitrile, ethanol and lower alcohols. Trichostatin A is sparingly soluble in chloroform, ethyl acetate, acetone, and benzene. However, it is insoluble in water.

Hazard Codes	Xn
Risk Statements	20/21/22-36/37/38-43
Safety Statements	26-36
RIDADR	NONH for all modes of transport
WGK Germany	WGK 3

Purity	≥98% (HPLC)
Storage Temp.	−20°C
UNSPSC	12352200

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