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T0070907

SIGMA/T8703 - ≥98% (HPLC)

Synonym: 2-Chloro-5-nitro-N-4-pyridinyl-benzamide; Benzamide, 2-chloro-5-nitro-N-4-pyridinyl-

CAS Number: 313516-66-4
Empirical Formula (Hill Notation): C12H8ClN3O3
Molecular Weight: 277.66
MDL Number: MFCD00121849
Linear Formula: C12H8ClN3O3
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-T8703-5MG 5 mg
 $174.00
1/EA		 Add To Favorites
45-T8703-25MG 25 mg
 $699.00
1/EA		 Add To Favorites

 

assay ≥98% (HPLC)
color white
form powder
InChI 1S/C12H8ClN3O3/c13-11-2-1-9(16(18)19)7-10(11)12(17)15-8-3-5-14-6-4-8/h1-7H,(H,14,15,17)
InChI key FRPJSHKMZHWJBE-UHFFFAOYSA-N
Quality Level 100 
SMILES string [O-][N+](=O)c1ccc(Cl)c(c1)C(=O)Nc2ccncc2
solubility DMSO: >10 mg/mL
  H2O: insoluble
storage temp. 2-8°C
Application: T0070907 has been used to reduce peroxisome proliferator-activated receptor gamma (PPAR-γ) expression in lipopolysaccharide (LPS)-induced leukemia RAW264.7 cell line. It also has been used to evaluate the involvement of wogonin in alleviating EtOH (ethanol)-induced inflammation in RAW264.7 cell line.
Application: T0070907 or Benzamide has been used as a ADP-ribosyltransferase (ADPRT) inhibitor in rat hippocampal slices. It has also been used for urine analysis in patients diagnosed with acute uncomplicated urinary tract infection.
Biochem/physiol Actions: T0070907 is very similar in structure and activity to the PPAR-γ antagonist GW9662. T0070907 is more potent and has higher selectivity for PPAR-γ over all other subtypes (about 800-fold) whereas GW9662 has been reported to have some PPAR-α agonist activity.
Features and Benefits: This compound is featured on the Nuclear Receptors (PPARs)  page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here .
General description: T0070907 has antimicrotubule, antitumor and radiosensitizing properties. It decreases tubulin protein levels, which is associated with cell cycle arrest, apoptosis and also reduces metastasis of colorectal carcinoma cells. T0070907 is used as a therapeutic target in breast cancer. It stimulates proteasome-dependent degradation of tubulin.
Packaging: 5, 25 mg in glass bottle
Preparation Note: T0070907 is soluble in DMSO at a concentration that is greater than 10 mg/ml.
Hazard Codes Xn
Risk Statements 22-36
Safety Statements 26
RIDADR NONH for all modes of transport
WGK Germany WGK 2
Purity ≥98% (HPLC)
Storage Temp. 2-8°C
UNSPSC 12352203

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