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Terbinafine hydrochloride

SIGMA/T8826

Synonym: trans-N-(6,6-Dimethyl-2-hepten-4-ylyl)-N-methyl-1-naphthylmethylamine hydrochloride

CAS Number: 78628-80-5
Empirical Formula (Hill Notation): C21H25N · HCl
Molecular Weight: 327.89
MDL Number: MFCD00145430
Linear Formula: C21H25N · HCl
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-T8826-100MG 100 mg
 $120.00
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45-T8826-250MG 250 mg
 $280.00
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This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material.

This image depicts SKU: T8826-100MG
This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material.

This image depicts SKU: T8826-250MG

 

antibiotic activity spectrum fungi
  yeast
assay ≥98% (HPLC)
biological source synthetic
color white
form powder
InChI 1S/C21H25N.ClH/c1-21(2,3)15-8-5-9-16-22(4)17-19-13-10-12-18-11-6-7-14-20(18)19;/h5-7,9-14H,16-17H2,1-4H3;1H/b9-5+;
InChI key BWMISRWJRUSYEX-SZKNIZGXSA-N
mode of action enzyme | inhibits
Quality Level 200 
SMILES string Cl[H].[H]C(CN(C)Cc1cccc2ccccc12)=C([H])C#CC(C)(C)C
solubility methanol: soluble 50 mg/mL
Application: Terbinafine hydrochloride is a synthetic allylamine antifungal. It is used to treat dermatophyte infections of the toenail/fingernail, ringworm and jock itch. It is used in adsorption, partition and stability studies.
Biochem/physiol Actions: Mode of Action: Inhibits squalene epoxidase, preventing biosynthesis of ergosterol.
Antimicrobial spectrum: Antifungal and antimycotic. Fungicidal against dermatopytes and some yeasts; fungistatic against Candida albicans.
Biochem/physiol Actions: Terbinafine inhibits squalene monooxygenase thereby blocking the biosynthesis of ergosterol, which is an essential component of fungal cell membranes. The inhibition of squalene monooxygenase also results in the accumulation of squalene. Terbinafine hydrochloride is highly lipophilic and tends to accumulate in skin, nails, and fatty tissues. It is antifungal and antimycotic. It is fungicidal against dermatopytes and some yeasts and is fungistatic against Candida albicans.
General description: Allylamine derivative.
Other Notes: Keep container tightly closed in a dry and well-ventilated place.Keep in a dry place.
Packaging: 100, 250 mg in poly bottle
Purity ≥98% (HPLC)
UNSPSC 51101500

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