Terbinafine hydrochloride

SIGMA/T8826

Synonym: trans-N-(6,6-Dimethyl-2-hepten-4-ylyl)-N-methyl-1-naphthylmethylamine hydrochloride

CAS Number: 78628-80-5
Empirical Formula (Hill Notation): C₂₁H₂₅N · HCl
Molecular Weight: 327.89
MDL Number: MFCD00145430
Linear Formula: C₂₁H₂₅N · HCl
Product Type: Chemical

Catalog Number	PKG Qty.	Price


45-T8826-100MG	100 mg	$132.00 1/EA	Add To Favorites
45-T8826-250MG	250 mg	$308.00 1/EA	Add To Favorites

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This image depicts SKU: T8826-100MG

Properties
Descriptions
Safety Info.
Basic Data

antibiotic activity spectrum	fungi
	yeast
assay	≥98%
color	white to faint beige
form	powder
InChI	1S/C21H25N.ClH/c1-21(2,3)15-8-5-9-16-22(4)17-19-13-10-12-18-11-6-7-14-20(18)19;/h5-7,9-14H,16-17H2,1-4H3;1H/b9-5+;
InChI key	BWMISRWJRUSYEX-SZKNIZGXSA-N
mode of action	enzyme \| inhibits
Quality Level	200
SMILES string	Cl[H].[H]C(CN(C)Cc1cccc2ccccc12)=C([H])C#CC(C)(C)C
solubility	methanol: soluble 50 mg/mL

Application:	Terbinafine hydrochloride is a synthetic allylamine antifungal. It is used to treat dermatophyte infections of the toenail/fingernail, ringworm and jock itch. It is used in adsorption, partition and stability studies.
Biochem/physiol Actions:	Mode of Action: Inhibits squalene epoxidase, preventing biosynthesis of ergosterol.Antimicrobial spectrum: Antifungal and antimycotic. Fungicidal against dermatopytes and some yeasts; fungistatic against Candida albicans.
Biochem/physiol Actions:	Terbinafine inhibits squalene monooxygenase thereby blocking the biosynthesis of ergosterol, which is an essential component of fungal cell membranes. The inhibition of squalene monooxygenase also results in the accumulation of squalene. Terbinafine hydrochloride is highly lipophilic and tends to accumulate in skin, nails, and fatty tissues. It is antifungal and antimycotic. It is fungicidal against dermatopytes and some yeasts and is fungistatic against Candida albicans.
Disclaimer:	The product is not intendedfor use as a biocide under global biocide regulations, including but notlimited to US EPA′s Federal Insecticide Fungicide and Rodenticide Act, EuropeanBiocidal Products Regulation, Canada’s Pest Management Regulatory Agency, Turkey’sBiocidal Products Regulation, Korea’s Consumer Chemical Products and BiocideSafety Management Act (K-BPR) and others.
General description:	Allylamine derivative.
Other Notes:	Keep container tightly closed in a dry and well-ventilated place.Keep in a dry place.
Packaging:	100, 250 mg in poly bottle

Symbol	GHS07,GHS09
Signal word	Warning
Hazard statements	H315 - H319 - H335 - H410
Precautionary statements	P273 - P302 + P352 - P305 + P351 + P338
Hazard Codes	Xi,N
Risk Statements	36/37/38-50/53
Safety Statements	26-60-61
RIDADR	UN 3077 9 / PGIII
WGK Germany	WGK 3

Purity	≥98%
UNSPSC	51302503

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