Terbinafine hydrochloride
SIGMA/T8826
Synonym: trans-
CAS Number: 78628-80-5
Empirical Formula (Hill Notation): C21H25N · HCl
Molecular Weight: 327.89
MDL Number: MFCD00145430
Linear Formula: C21H25N · HCl
Product Type: Chemical
antibiotic activity spectrum | fungi |
yeast | |
assay | ≥98% (HPLC) |
biological source | synthetic |
color | white |
form | powder |
InChI | 1S/C21H25N.ClH/c1-21(2,3) |
InChI key | BWMISRWJRUSYEX-SZKNIZGXSA |
mode of action | enzyme | inhibits |
Quality Level | 200 ![]() |
SMILES string | Cl[H].[H]C(CN(C)Cc1cccc2 |
solubility | methanol: soluble 50 mg/mL |
Application: | Terbinafine hydrochloride is a synthetic allylamine antifungal. It is used to treat dermatophyte infections of the toenail/fingernail, ringworm and jock itch. It is used in adsorption, partition and stability studies. |
Biochem/physiol Actions: | Mode of Action: Inhibits squalene epoxidase, preventing biosynthesis of ergosterol. Antimicrobial spectrum: Antifungal and antimycotic. Fungicidal against dermatopytes and some yeasts; fungistatic against Candida albicans. |
Biochem/physiol Actions: | Terbinafine inhibits squalene monooxygenase thereby blocking the biosynthesis of ergosterol, which is an essential component of fungal cell membranes. The inhibition of squalene monooxygenase also results in the accumulation of squalene. Terbinafine hydrochloride is highly lipophilic and tends to accumulate in skin, nails, and fatty tissues. It is antifungal and antimycotic. It is fungicidal against dermatopytes and some yeasts and is fungistatic against Candida albicans. |
General description: | Allylamine derivative. |
Other Notes: | Keep container tightly closed in a dry and well-ventilated place.Keep in a dry place. |
Packaging: | 100, 250 mg in poly bottle |
Symbol | ![]() ![]() |
Signal word | Warning |
Hazard statements | H315 - H319 - H335 - H410 |
Precautionary statements | P273 - P302 + P352 - P305 + P351 + P338 |
Hazard Codes | Xi,N |
Risk Statements | 36/37/38-50/53 |
Safety Statements | 26-60-61 |
RIDADR | UN 3077 9 / PGIII |
WGK Germany | WGK 3 |
Purity | ≥98% (HPLC) |
UNSPSC | 51101500 |