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Thiostrepton from Streptomyces azureus

SIGMA/T8902 - ≥90% (HPLC)

Synonym: Bryamycin; NSC 170365; NSC 81722; Thiactin; Thiostreptin A

CAS Number: 1393-48-2
Empirical Formula (Hill Notation): C72H85N19O18S5
Molecular Weight: 1664.89
EC Number: 215-734-9
MDL Number: MFCD00135828
Linear Formula: C72H85N19O18S5
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-T8902-1G 1 g
 $180.00
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This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material. This image depicts SKU: T8902-1G

 

antibiotic activity spectrum Gram-negative bacteria
  Gram-positive bacteria
  parasites
assay ≥90% (HPLC)
InChI 1S/C72H85N19O18S5/c1-14-26(3)47-63(105)78-30(7)57(99)75-28(5)56(98)76-31(8)58(100)91-72-19-18-40(66-85-43(22-111-66)59(101)77-29(6)55(97)74-27(4)54(73)96)81-52(72)42-21-112-67(83-42)49(34(11)109-69(107)41-20-37(32(9)92)36-16-17-39(79-47)51(95)50(36)80-41)89-60(102)44-24-113-68(86-44)53(71(13,108)35(12)94)90-62(104)45-23-110-65(84-45)38(15-2)82-64(106)48(33(10)93)88-61(103)46-25-114-70(72)87-46/h15-17,20-22,24-26,30-35,39,45,47-49,51-53,79,92-95,108H,4-6,14,18-19,23H2,1-3,7-13H3,(H2,73,96)(H,74,97)(H,75,99)(H,76,98)(H,77,101)(H,78,105)(H,82,106)(H,88,103)(H,89,102)(H,90,104)(H,91,100)/b38-15-
InChI key NSFFHOGKXHRQEW-BXVAPQLOSA-N
mode of action protein synthesis | interferes
Quality Level 200 
SMILES string CCC(C)C1NC2C=Cc3c(cc(nc3C2O)C(=O)OC(C)C4NC(=O)c5csc(n5)C(NC(=O)C6CSC(=N6)C(NC(=O)C(NC(=O)c7csc(n7)C8(CCC(=NC8c9csc4n9)c%10nc(cs%10)C(=O)NC(=C)C(=O)NC(=C)C(N)=O)NC(=O)C(C)NC(=O)C(=C)NC(=O)C(C)NC1=O)C(C)O)=CC)C(C)(O)C(C)O)C(C)O
solubility acetic acid: soluble 25 mg/mL, clear to hazy, yellow to brownish-yellow
storage temp. −20°C
Application: Thiostrepton has been used as a selectable marker for recombinant Streptomyces cultures,,.
Biochem/physiol Actions: Peptide antibiotic that prevents the binding of elongation factor G (EF-G) and GTP to the 50S ribosomal subunit.
General description: Chemical structure: peptide
Packaging: 1 g in poly bottle
Preparation Note: Thiostrepton dissolves in acetic acid at 25 mg/ml to yield a clear to hazy, yellow-yellow brown solution.
Hazard Codes Xn
Risk Statements 22
RIDADR NONH for all modes of transport
WGK Germany WGK 3
Flash Point(F) Not applicable
Flash Point(C) Not applicable
Purity ≥90% (HPLC)
Storage Temp. −20°C
UNSPSC 12352200

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