Thiostrepton from Streptomyces azureus
SIGMA/T8902 - ≥90% (HPLC)
Synonym: Bryamycin; NSC 170365; NSC 81722; Thiactin; Thiostreptin A
CAS Number: 1393-48-2
Empirical Formula (Hill Notation): C72H85N19O18S5
Molecular Weight: 1664.89
EC Number: 215-734-9
MDL Number: MFCD00135828
Linear Formula: C72H85N19O18S5
Product Type: Chemical
antibiotic activity spectrum | Gram-negative bacteria |
Gram-positive bacteria | |
parasites | |
assay | ≥90% (HPLC) |
InChI | 1S/C72H85N19O18S5/c1-14-2 |
InChI key | NSFFHOGKXHRQEW-BXVAPQLOSA |
mode of action | protein synthesis | interferes |
Quality Level | 200 |
SMILES string | CCC(C)C1NC2C=Cc3c(cc(nc3C |
solubility | acetic acid: soluble 25 mg/mL, clear to hazy, yellow to brownish-yellow |
storage temp. | −20°C |
Application: | Thiostrepton has been used as a selectable marker for recombinant Streptomyces cultures,,. |
Biochem/physiol Actions: | Peptide antibiotic that prevents the binding of elongation factor G (EF-G) and GTP to the 50S ribosomal subunit. |
General description: | Chemical structure: peptide |
Packaging: | 1 g in poly bottle |
Preparation Note: | Thiostrepton dissolves in acetic acid at 25 mg/ml to yield a clear to hazy, yellow-yellow brown solution. |
Hazard Codes | Xn |
Risk Statements | 22 |
RIDADR | NONH for all modes of transport |
WGK Germany | WGK 3 |
Flash Point(F) | Not applicable |
Flash Point(C) | Not applicable |
Purity | ≥90% (HPLC) |
Storage Temp. | −20°C |
UNSPSC | 12352200 |