Thiabendazole
SIGMA/T8904 - ≥99%, powder
Synonym: 2-
CAS Number: 148-79-8
Empirical Formula (Hill Notation): C10H7N3S
Molecular Weight: 201.25
EC Number: 205-725-8
MDL Number: MFCD00005587
Linear Formula: C10H7N3S
Product Type: Chemical
This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material. This image depicts SKU: T8904-500G
This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material. This image depicts SKU: T8904-100G
| antibiotic activity spectrum | fungi |
| parasites | |
| assay | ≥99% |
| color | white to off-white |
| form | powder |
| InChI | 1S/C10H7N3S/c1-2-4-8-7(3- |
| InChI key | WJCNZQLZVWNLKY-UHFFFAOYSA |
| mode of action | enzyme | inhibits |
| Quality Level | 200  |
| SMILES string | c1ccc2[nH]c(nc2c1)-c3cscn |
| solubility | DMF: soluble 50 mg/mL |
| Application: | Thiabendazole (TBZ) is a broad-spectrum antihelminthic and is used to treat parasitic infections in humans. It is used as an agricultural fungicide and as a food preservative. Thiabendazole has been used as a heavy metal chelating detoxification agent. It is used clinically to treat threadworm, cutaneous larva migrans, visceral larva migrans, and trichinosis. |
| Biochem/physiol Actions: | Thiabendazole inhibits anaerobic respiration at the level of mitochondrial helminth-specific enzyme. It acts as a quinol-fumarate reductase (QFR) inhibitor in ,C. jejuni and H. pylori, blocking quinol oxidation to quinone. Thiabendazole suppresses egg and larval production and may inhibit the subsequent development of eggs and larvae which are passed in feces. A proposed route of biotransformation of thiabendazole is the CYP1A2-catalyzed hydroxylation to 5-hydroxythiabendazole, which is metabolized to glucuronide and sulfate conjugates. |
| General description: | Chemical structure: imidazole |
| Other Notes: | Keep container tightly closed in a dry and well-ventilated place.Keep in a dry place.Storage class (TRGS 510): Non Combustible Solids |
| Packaging: | 100, 500 g in glass bottle |
| Symbol |  GHS09 |
| Signal word | Warning |
| Hazard statements | H410 |
| Precautionary statements | P273 - P501 |
| Hazard Codes | N |
| Risk Statements | 50/53 |
| Safety Statements | 60-61 |
| RIDADR | UN 3077 9 / PGIII |
| WGK Germany | WGK 2 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Purity | ≥99% |
| UNSPSC | 51453501 |