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Thyrotropic hormone from bovine pituitary

SIGMA/T8931

Synonym: TSH; Thyroid stimulating hormone; Thyrotropin from bovine pituitary glands

CAS Number: 9002-71-5
MDL Number: MFCD00166060
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-T8931-1VL 1 vial
 $299.00
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45-T8931-10VL 10 vials
 $1810.00
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biological source bovine pituitary glands
form powder
packaging vial of 100 μg
Quality Level 200 
storage temp. 2-8°C
technique(s) cell culture | mammalian: suitable
UniProt accession no. P01223 
  P16473 
Analysis Note: Contains phosphate buffer salts
Application: Thyrotropic hormone from bovine pituitary has been used:
• to induce cAMP production in orbital fibroblasts.
• as a component in Dulbecco modified eagle medium (DME) H-21:F-12 media.
• for TSH stimulation test for assessing the thyroid gland function after nonthyroidal illness (NTI) induction.
• for studying the thyrotropin involvement in photoperiodic signal transduction in mice.
Biochem/physiol Actions: Thyrotropin/thyroid-stimulating hormone (TSH) helps to regulate thyroid function. In children, TSH plays a vital role in normal cognition and neurodevelopment. Circulating TSH is capable of binding to cell surface receptors in the thyroid gland. This hormone induces thyroid to produce thyroglobulin and the thyroid hormones. TSH can also promote the uptake of iodine (131I) in individuals with thyroid cancer. It can also enhance vascular endothelial growth factor (VEGF) secretion and angiogenesis in thyroid cancer cell lines.
Biochem/physiol Actions: Two-chain glycoprotein hormone. The α-chain is not active, biological specificity attributed rather to the β-chain. Activates adenylate cyclase in the thyroid gland, stimulating iodine uptake, thyroxine synthesis and release. Goitrogenic.
General description: Thyrotropin/thyroid-stimulating hormone (TSH) belongs to the glycoprotein hormone family. This glycoprotein is produced by thyrotroph cells of the anterior pituitary gland. It circulates in free form and possess a short plasma half-life.
Packaging: 1 vial in serum bottle
Packaging: 10 vials in serum bottle
RIDADR NONH for all modes of transport
WGK Germany WGK 3
Flash Point(F) Not applicable
Flash Point(C) Not applicable
Storage Temp. 2-8°C
UNSPSC 51111800

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