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Telmisartan

SIGMA/T8949 - ≥98% (HPLC), solid

Synonym: 4′[(1,4′-Dimethyl-2′-propyl[2,6′-bi-1H-benzimidazol]-1′-yl)methyl][1,1′-biphenyl]-2-carboxylic acid; BIBR 277

CAS Number: 144701-48-4
Empirical Formula (Hill Notation): C33H30N4O2
Molecular Weight: 514.62
MDL Number: MFCD00918125
Linear Formula: C33H30N4O2
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-T8949-10MG 10 mg
 $215.00
1/EA		 Add To Favorites
45-T8949-50MG 50 mg
 $825.00
1/EA		 Add To Favorites

 

assay ≥98% (HPLC)
color white
form solid
InChI 1S/C33H30N4O2/c1-4-9-30-35-31-21(2)18-24(32-34-27-12-7-8-13-28(27)36(32)3)19-29(31)37(30)20-22-14-16-23(17-15-22)25-10-5-6-11-26(25)33(38)39/h5-8,10-19H,4,9,20H2,1-3H3,(H,38,39)
InChI key RMMXLENWKUUMAY-UHFFFAOYSA-N
originator Boehringer Ingelheim
Quality Level 100 
SMILES string CCCc1nc2c(C)cc(cc2n1Cc3ccc(cc3)-c4ccccc4C(O)=O)-c5nc6ccccc6n5C
solubility DMSO: >5 mg/mL at 60 °C
  H2O: insoluble
Application: Telmisartan has been used as an AT1 receptor antagonist to study its effects on mouse models of myocardial infarction. This study reported that telmisartan inhibited the CCN1 upregulation and reduced CCN2 levels atrial cardiomyocytes. Telmisartan has also been used to evaluate its effect on the expression of CCN1 in kidney cortex of mice subjected to myocardial infarction. Furthermore, telmisartan has been used to test its efficacy against tumor growth in mouse models of colorectal cancer.
Biochem/physiol Actions: Telmisartan is a non-peptide AT1 angiotensin receptor antagonist.
Features and Benefits: This compound is a featured product for ADME Tox research. Click here  to discover more featured ADME Tox products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm .
Features and Benefits: This compound is featured on the Angiotensin Receptors  page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here .
Features and Benefits: This compound was developed by Boehringer Ingelheim . To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here .
Packaging: 10, 50 mg in glass bottle
Preparation Note: Telmisartan is soluble in DMSO at a concentration that is greater than 5 mg/ml. It is insoluble in water.
RIDADR NONH for all modes of transport
WGK Germany WGK 2
Flash Point(F) Not applicable
Flash Point(C) Not applicable
Purity ≥98% (HPLC)
UNSPSC 12352200

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