Synonym: 4′,5,6,7,8-Pentamethoxyflavone; 5,6,7,8-Tetramethoxy-2-(4-methoxyphenyl)-4H-1-benzopyran-4-one; NSC 53909; NSC 618905; Ponkanetin
CAS Number: 481-53-8
Empirical Formula (Hill Notation): C20H20O7
Molecular Weight: 372.37
EC Number: 207-570-1
MDL Number: MFCD00017438
Linear Formula: C20H20O7
Product Type: Chemical
| assay |
≥95% (HPLC) |
| InChI |
1S/C20H20O7/c1-22-12-8-6-11(7-9-12)14-10-13(21)15-16(23-2)18(24-3)20(26-5)19(25-4)17(15)27-14/h6-10H,1-5H3 |
| InChI key |
ULSUXBXHSYSGDT-UHFFFAOYSA-N |
| Quality Level |
100  |
| SMILES string |
COc1ccc(cc1)C2=CC(=O)c3c(OC)c(OC)c(OC)c(OC)c3O2 |
| Application: |
Tangeretin has been used as an antioxidant and antifungal agent to test its effects on ferroptosis inhibition, conidial development, and appressorium formation against Magnaporthe oryzae. It has also been used as a co-chemotherapeutics agent to study its cytotoxic effects in combination with 5-Fluorouracil (5-Fu) on WiDr colon cancer cells. |
| Biochem/physiol Actions: |
Tangeretin displays its anti-cancer effects by modulating different pathways in several cancer types in both in-vitro and in-vivo studies. It also exerts antioxidant, anti-inflammatory, and estrogenic properties. |
| Biochem/physiol Actions: |
Tangeretin is a flavonoid found in the peel of citrus fruits where it most likely provides natural resistance to fungi. Tangeretin has been shown to counteract tumor promoter-induced inhibition of intercellular communication and to inhibit cell proliferation in several cancer lines. |
| General description: |
Tangeretin is a polymethoxyflavone extracted primarily from the peels of citrus fruits like Citrus sinensis and Citrus reticulata. |
| Packaging: |
5, 10 mg in glass bottle |
| Hazard Codes |
T |
| Risk Statements |
25 |
| Safety Statements |
45 |
| RIDADR |
UN 2811 6.1 / PGIII |
| WGK Germany |
WGK 3 |
| Purity |
≥95% (HPLC) |
| UNSPSC |
12352205 |
