TAS-301
SIGMA/T9324 - ≥95% (HPLC), solid
Synonym: 3-
CAS Number: 193620-69-8
Empirical Formula (Hill Notation): C23H19NO3
Molecular Weight: 357.40
MDL Number: MFCD05865245
Linear Formula: C23H19NO3
Product Type: Chemical
assay | ≥95% (HPLC) |
form | solid |
InChI | 1S/C23H19NO3/c1-26-17-11- |
InChI key | KUEYYIJXBRWZIB-UHFFFAOYSA |
Quality Level | 100 ![]() |
SMILES string | COc1ccc(cc1)C(c2ccc(OC)c |
solubility | DMSO: 40 mg/mL |
Biochem/physiol Actions: | Inhibitor of migration and proliferation in vascular smooth muscle cells; inhibitor of restenosis. |
Biochem/physiol Actions: | TAS-301 is known to block intimal thickening post balloon injury in rat carotid arteries. It inhibits intimal thickening by blocking Ca2+/calmodulin-dependent protein kinase II (CaM kinase II) and cytoskeletal depolymerization. Moreover, TAS 301 can also inhibit receptor-regulated influx of calcium in rat vascular smooth muscle cells (VSMCs). |
Packaging: | 10 mg in glass bottle |
Preparation Note: | TAS-301 is soluble in DMSO at 40 mg/ml. |
RIDADR | NONH for all modes of transport |
WGK Germany | WGK 3 |
Flash Point(F) | Not applicable |
Flash Point(C) | Not applicable |
Purity | ≥95% (HPLC) |
UNSPSC | 12352200 |