Synonym: 8-Chloro-6-[2-chlorophenyl]-1-methyl-4H-[1,2,4]triazolo[4,3-a][1,4]benzodiazepine
CAS Number: 28911-01-5
Empirical Formula (Hill Notation): C17H12Cl2N4
Molecular Weight: 343.21
EC Number: 249-307-3
MDL Number: MFCD00079623
Linear Formula: C17H12Cl2N4
Product Type: Chemical
| drug control |
USDEA Schedule IV; Home Office Schedule 4.1; psychotrope (France); kontrollierte Droge in Deutschland; regulated under CDSA - not available from Sigma-Aldrich Canada; psicótropo (Spain); Decreto Lei 15/93: Tabela IV (Portugal) |
| InChI |
1S/C17H12Cl2N4/c1-10-21-22-16-9-20-17(12-4-2-3-5-14(12)19)13-8-11(18)6-7-15(13)23(10)16/h2-8H,9H2,1H3 |
| InChI key |
JOFWLTCLBGQGBO-UHFFFAOYSA-N |
| originator |
Johnson & Johnson |
| Quality Level |
200  |
| SMILES string |
ClC1=CC=CC=C1C2=NCC3=NN=C(C)N3C4=CC=C(Cl)C=C42 |
| solubility |
0.1 M HCl: soluble 1 g in 600 mL solvent |
| |
chloroform: soluble 1 g in 25 mL solvent |
| |
dichloromethane: 50 mg/mL, clear, colorless to faintly yellow |
| |
diethyl ether: insoluble |
| |
DMSO: soluble 5.4 mg/mL |
| |
ethanol: soluble 1 g in 1000 mL solvent |
| |
H2O: insoluble |
| |
methanol: soluble 8.8 mg/mL |
| Application: |
Triazolam has been used to define nonspecific binding in radioligand binding assays. Triazolam has also been used to study the effects of reducing mPer1 mRNA levels in mouse cerbellum. |
| Biochem/physiol Actions: |
Anxiolytic; ligand for the GABAA receptor benzodiazepine modulatory site. |
| Features and Benefits: |
This compound is a featured product for ADME Tox research. Click here to discover more featured ADME Tox products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm . |
| Features and Benefits: |
This compound was developed by Johnson & Johnson . To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here . |
| Preparation Note: |
Triazolam is soluble in dichloromethane at 50 mg/ml, with heat as needed, yielding a clear, colorless to faint yellow solution. Furthermore, 1g of triazolam is soluble in 25 mL chloroform, 1000 mL ethanol, and 600 mL 0.1 M HCl. It is also soluble in DMSO (5.4 mg/ml) and methanol (8.8 mg/ml). However, it is insoluble in water and in ether. |
| RIDADR |
NONH for all modes of transport |
| WGK Germany |
WGK 2 |
| Flash Point(F) |
Not applicable |
| Flash Point(C) |
Not applicable |
