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Tau-352 human

SIGMA/T9950 - recombinant, expressed in E. coli, ≥90% (SDS-PAGE), lyophilized powder

MDL Number: MFCD07785730
Product Type: Chemical

Catalog Number PKG Qty. Price Quantity
45-T9950-50UG 50 µg
$618.00
1/EA
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application(s) cell analysis
assay ≥90% (SDS-PAGE)
biological source human
form lyophilized powder
mol wt 36.8 kDa
Quality Level 200 
recombinant expressed in E. coli
shipped in wet ice
storage temp. −20°C
UniProt accession no. P10636 
Application: Tau-352 human is a Tau isoform, variant 0N3R which means it consists of 3 microtubule binding repeats (R) and no amino terminal inserts (N). The product can be utilized for systemic identification of Phosphorylation sites in microtubule-associated protein tau by using checkpoint kinases Chk1 and Chk2 in vitro.
Biochem/physiol Actions: Isoform of Tau, variant 0N3R, having 3 microtubule binding repeats (R) and no amino terminal inserts (N).
Biochem/physiol Actions: Tau-383 human belongs to neuronal microtubule-associated protein family that stimulates the microtubule assembly and stability as well as facilitates hyperphosphorylation-induced self-assembly into filaments. Tau protein along with src can upregulate tyrosine kinase activity. Inhibition of Src kinase influences the action of tau on actin rearrangements which in turn impacts the growth-factor-induced actin remodeling.
Reconstitution: Lyophilized from MES, pH 6.8, containing NaCl and EGTA. When reconstituted in water to a protein concentration of 1 mg/mL, the resulting buffer will have ~50 mM MES, pH 6.8, 100 mM NaCl, and 0.5 mM EGTA.
RIDADR NONH for all modes of transport
WGK Germany WGK 1
Flash Point(F) Not applicable
Flash Point(C) Not applicable
Purity ≥90% (SDS-PAGE)
Storage Temp. −20°C
UNSPSC 12352200

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