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TrueGel3D Crosslinker

SIGMA/TRUECD - CD cell-degradable crosslinker

Synonym: Crosslinker

Product Type: Chemical

Catalog Number PKG Qty. Price Quantity
45-TRUECD-200UL 200 µL
$216.00
1/EA
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45-TRUECD-600UL 600 µL
$536.00
1/EA
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Cyst formation of MDCK cells in TrueGel hydrogel

 

shipped in dry ice
storage temp. −20°C
Application: TRUECD is used to crosslink PVA and dextran polymers to generate cell-degradable hydrogel
Disclaimer: Avoid prolong exposure of CD cell-degradable crosslinker to air
Features and Benefits: MMP degradable
General description: CD cell-degradable crosslinker is comprised of conjugated peptide along with polyethylene glycol and thiol (SH) groups. The thiol groups form stable thioether bond with thiol-reactive groups of the polymers (Mal-PVA, Mal-Dextran, SG-PVA and SG-Dextran) and results in a stable hydrogel.

The conjugated peptide has matrix metalloprotease (MMP)-cleavage sites (Pro-Leu-Gly-Leu-Trp-Ala), which allows matrix metalloproteases (MMP1, MMP3, MMP7 and MMP9) to locally degrade the polymer network. It allows cells to spread and migrate within the gel if they express the indicated MMPs.
Other Notes: TRUECD contains CD cell-degradable crosslinker lyophilized and water.
RIDADR NONH for all modes of transport
Storage Temp. −20°C
UNSPSC 12352207

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