TrueGel3D Polymer
SIGMA/TRUEPVAF - modified for fast gelling (FAST-PVA)
Product Type: Chemical
Cyst formation of MDCK cells in TrueGel hydrogel
| biological source | synthetic |
| shipped in | dry ice |
| storage temp. | −70°C |
| technique(s) | cell attachment: suitable |
| Application: | FAST-PVA polymer is used with crosslinkers (CD/PEG crosslinkers) to establish stable hydrogels. |
| Disclaimer: | Avoid frequent freeze-thaw cycles and store FAST-PVA polymer in small portions. |
| Features and Benefits: | • Contains synthetic polymer (PVA) functionalized with maleimide groups for quick gelation • Non degradable polymer |
| General description: | PVA polymers are functionalized with thiol-reactive maleimide groups, which react rapidly with thiol groups of crosslinkers to form hydrogels in few seconds. The thiol-reactive maleimide groups are also compatible to conjugate polymers with bioactive factors. The thioglycerol is used to maintain hydrogel strength and also as a control to compare cellular behavior in peptide-modified versus unmodified hydrogels. The buffers (pH7.2 and pH 5.5) are used to control pH and osmotic conditions to optimize time for gelation. |
| Other Notes: | TRUEPVAF contains FAST-PVA solution in phosphate buffer, TrueGel3D thioglycerol and water. |
| Symbol |  GHS05 |
| Signal word | Warning |
| Hazard statements | H290 |
| Precautionary statements | P234 - P390 |
| RIDADR | UN 1789 8 / PGIII |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Storage Temp. | −70°C |
| UNSPSC | 12352207 |