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UK 14,304

SIGMA/U104

Synonym: 5-Bromo-N-(2-imidazolin-2-yl)-6-quinoxalinamine; 5-Bromo-N-(4,5-dihydro-1H-imidazol-2-yl)-6-quinoxalinamine; Brimonidine

CAS Number: 59803-98-4
Empirical Formula (Hill Notation): C11H10BrN5
Molecular Weight: 292.13
MDL Number: MFCD00153878
Linear Formula: C11H10BrN5
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-U104-5MG 5 mg
 $90.00
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45-U104-25MG 25 mg
 $329.00
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45-U104-100MG 100 mg
 $1050.00
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InChI 1S/C11H10BrN5/c12-9-7(17-11-15-5-6-16-11)1-2-8-10(9)14-4-3-13-8/h1-4H,5-6H2,(H2,15,16,17)
InChI key XYLJNLCSTIOKRM-UHFFFAOYSA-N
Quality Level 100 
SMILES string Brc1c(NC2=NCCN2)ccc3nccnc13
solubility 45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: <0.8 mg/mL
  DMSO: >6.5 mg/mL
  ethanol: <8 mg/mL (warm)
  H2O: insoluble
Application: UK 14,304 has been used for the activation of extracellular signal-regulated kinase (ERK) in epicardial coronary artery culture
Application: UK 14,304 has been used in myenteric neurons to study the inhibition of R-type calcium currents. UK 14,304 has also been used for immunofluorescence microscopy assays.
Biochem/physiol Actions: UK 14,304 is an α2-adrenoceptor agonist. UK 14,304 inhibits hormone-sensitive lipase (HSL) activity and suppresses lipogenesis in adipose tissue.
Features and Benefits: This compound is featured on the α2-Adrenoceptors  page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here .
Packaging: 5, 25, 100 mg in glass bottle
Preparation Note: UK 14,304 is soluble in 45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin (<0.8 mg/mL), DMSO (>6.5 mg/ml) and ethanol (<8 mg/mL). However, it is insoluble in water.
Symbol GHS06  GHS06
Signal word Danger
Hazard statements H301
Precautionary statements P301 + P310
Hazard Codes T
Risk Statements 25
Safety Statements 45
RIDADR UN 2811 6.1 / PGIII
WGK Germany WGK 1
Flash Point(F) Not applicable
Flash Point(C) Not applicable
UNSPSC 12352200

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