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DMT-2′O-TC-rU Phosphoramidite

SIGMA/U211680 - configured for PerkinElmer, configured for PolyGen

Synonym: O5′-(4,4′-dimethoxytrityl)-O2′-(1,1-dioxothiomorpholine-4-thiocarbonyl)uridine O3′-(O-(2-cyanoethyl)-N,N-diisopropylphosphoramidite)

CAS Number: 1219089-92-5
Empirical Formula (Hill Notation): C44H54N5O11PS2
Molecular Weight: 924.03
MDL Number: MFCD19105660
Linear Formula: C44H54N5O11PS2
Product Type: Chemical

Catalog Number PKG Qty. Price Quantity
45-U211680-1G 1 g
$605.00
1/EA
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λ conforms (UV/VIS Identity)
assay ≥98% (31P-NMR)
  ≥98.0% (reversed phase HPLC)
color white to light yellow
compatibility configured for PerkinElmer
  configured for PolyGen
form solid
impurities ≤0.3 wt. % water content (Karl Fischer)
  ≤0.5% 3′-TC isomer (reversed phase HPLC)
  ≤0.5% P(III) Impurities 145-155ppm (31P-NMR)
InChI 1S/C44H54N5O11PS2/c1-30(2)49(31(3)4)61(57-26-10-22-45)60-39-37(58-41(48-23-21-38(50)46-42(48)51)40(39)59-43(62)47-24-27-63(52,53)28-25-47)29-56-44(32-11-8-7-9-12-32,33-13-17-35(54-5)18-14-33)34-15-19-36(55-6)20-16-34/h7-9,11-21,23,30-31,37,39-41H,10,24-29H2,1-6H3,(H,46,50,51)/t37-,39-,40-,41-,61?/m1/s1
InChI key ZBEGZGQLSUITQX-WXSPLRIASA-N
nucleoside profile base: uridine
base protecting group: none
2' protecting group: TC
5' protecting group: DMT
deprotection: fast
product line Proligo Reagents
Quality Level 200 
SMILES string COc1ccc(cc1)C(OC[C@H]2O[C@H]([C@H](OC(=S)N3CCS(=O)(=O)CC3)[C@@H]2OP(OCCC#N)N(C(C)C)C(C)C)N4C=CC(=O)NC4=O)(c5ccccc5)c6ccc(OC)cc6
solubility acetonitrile: toluene (1:1): 0.1 M at 18 °C, clear
storage temp. −20°C
technique(s) oligo synthesis: suitable
Legal Information: For use with Customer Container sold to end user customers either directly or through distributors.

This product is manufactured and sold under a license from Agilent Technologies under under US Patent No. 8,202,983 and pending U.S. Patent App. Nos. 13/485,5925, 13/531,191, and 13/339,082 and corresponding foreign counterparts, including those issuing from PCT/US08/63342 and PCT/US09/057922 all assigned to Agilent Technologies. The purchase of this product conveys to the buyer the limited, non-exclusive, non-transferable right (without the right to resell, repackage, or further sublicense) under these patents to use the product to synthesize Oligonucleotides for buyer′s internal research use only, including commercial purposes. Except as otherwise provided herein, no other license is granted to the buyer weather expressly, by implication, by estoppel or otherwise. Buyer agrees and understands that it is not licensed to use this product to synthesize Oligonucleotides for sale, for diagnostic uses including use in clinical diagnostic settings where the use in conjunction with an individual′s sample generates data provided to an individual or the individual′s caregiver for a free reimbursement, neither can Oligonucleotides synthesized using this product be used for use clinical trials or for other therapeutic purposes. This product is sold pursuant to authorization from Agilent Technologies, Inc. and Agilent Technologies reserves all other rights under these patents.

For use with all sales where the purchaser is required to have its own direct license from Agilent, without limitation, Bulk Quantity Sales, and sales to Oligo Houses.

This product and it uses are covered by under US Patent No. 8,202,983 and pending U.S. Patent App. Nos. 13/485,5925, 13/531,191, and 13/339,082 and corresponding foreign counterparts, including those issuing from PCT/US08/63342 and PCT/US09/057922 all assigned to Agilent Technologies. This product is sold to purchaser pursuant to authorization by Agilent Technologies, Inc. without any rights conferred by seller, based on purchaser′s direct license and authorization to purchase from Agilent Technologies, Inc. No license is granted to the purchaser weather expressly, by implication, by estoppel or otherwise on account of this purchase. Purchase′s rights to use this product are governed solely and expressly by purchaser′s direct license agreement with Agilent.
Legal Information: These products are manufactured and sold under a license from Agilent Technologies under US Patent No. 8,202,983 and pending U.S. Patent App. Nos. 13/485,5925, 13/531,191, and 13/339,082 and corresponding foreign counterparts, including those issuing from PCT/US08/63342 and PCT/US09/057922 all assigned to Agilent Technologies.

These products and its uses are covered by US Patent No. 8,202,983 and pending U.S. Patent App. Nos. 13/485,5925, 13/531,191, and 13/339,082 and corresponding foreign counterparts, including those issuing from PCT/US08/63342 and PCT/US09/057922 all assigned to Agilent Technologies.
RIDADR NONH for all modes of transport
WGK Germany WGK 3
Flash Point(F) Not applicable
Flash Point(C) Not applicable
Purity ≥98% (31P-NMR); ≥98.0% (reversed phase HPLC)
Storage Temp. −20°C
UNSPSC 41116105

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