Ubiquitin Carrier Protein H2 human
SIGMA/U2508
MDL Number: MFCD04041190
Product Type: Chemical
| application(s) | cell analysis |
| assay | >95% (SDS-PAGE) |
| biological source | human |
| form | solution |
| mol wt | ~14 kDa |
| Quality Level | 200  |
| recombinant | expressed in E. coli (GST-tagged) |
| shipped in | dry ice |
| storage temp. | −70°C |
| UniProt accession no. | P61088  |
| P62256 |
| Biochem/physiol Actions: | UbcH2 is the human homolog to the yeast DNA repair gene RAD6 and is inducible by DNA damaging agents. Also associated with cancer-induced cachexia and the degradation of "N-end rule" substrates. UbcH2 mRNA level in muscle has also been correlated with sepsis. Moreover, c-Jun and c-Fos transcription factors have been shown to be ubiquitinated by an UbcH2-mediated event. |
| Biochem/physiol Actions: | UbcH2 is the human homolog to the yeast DNA repair gene RAD6 and is inducible by DNA damaging agents. Also associated with cancer-induced cachexia and the degradation of "N-end rule" substrates. UbcH2 mRNA level in muscle has also been correlated with sepsis. Moreover, c-Jun and c-Fos transcription factors have been shown to be ubiquitinated by an UbcH2-mediated event. TNF-α was shown to stimulate expression of UbcH2 in skeletal muscle cells by increasing binding of NFκ-B to the promoter region of UbcH2, inducing transcription. |
| Other Notes: | manufactured for Sigma by Boston Biochem. Inc. |
| Physical form: | Solution in 50 mM HEPES, 50 mM NaCl, 10% glycerol, 1mM DTT, pH 7.8 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 1 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Purity | >95% (SDS-PAGE) |
| Storage Temp. | −70°C |
| UNSPSC | 12352202 |