U 18666A
SIGMA/U3633 - powder
Synonym: (3β)-3-[2-(Diethylamino)ethoxy]androst-5-en-17-one hydrochloride
CAS Number: 3039-71-2
Empirical Formula (Hill Notation): C25H41NO2·HCl
Molecular Weight: 424.06
MDL Number: MFCD00210908
Linear Formula: C25H41NO2·HCl
Product Type: Chemical
assay | ≥98% (HPLC) |
color | white to off-white |
form | powder |
InChI | 1S/C25H41NO2.ClH/c1-5-26( |
InChI key | GZFYZYBWLCYBMI-MYZJJQSMSA |
mp | 195-196.5 °C (lit.) |
SMILES string | Cl[H].[H][C@@]12CC=C3C[C@ |
solubility | H2O: 10 mg/mL≥ |
storage temp. | 2-8°C |
Application: | U 18666A has been used in fibroblast controls to study the mechanism of increase in autophagy in Niemann-Pick Disease Type C (NPC) cells. |
Application: | U 18666A has been used: • as a competitive inhibitor of the Niemann-Pick disease, type C (NPC2) binding partner Niemann-Pick C1 (NPC1) to treat symbiotic and aposymbiotic adult Aiptasia to study the effect of global sterol transport inhibition • in treating seminiferous tubules to study its effects on the localization pattern of VPS35-positive vesicles • to study the U18666A treatment effects on early endosomes and late endosomes/multivesicular bodies (MVBs) • as an NPC1 inhibitor to test its in vivo efficacy and study its effects on filovirus entry and infection |
Biochem/physiol Actions: | Inhibitor of cholesterol synthesis (inhibits desmosterol Δ24-reductase). Weak inhibitor of hedgehog (hh) signaling. |
Biochem/physiol Actions: | U18666A, a Niemann-Pick phenotype inducer, can inhibit the lysosomal cholesterol export and Ebola infection. |
General description: | U18666A, a cationic amphiphile/sterol, has a diethylaminoethyl chain linked to the 3-hydroxyl. It is an androstenolone derivative. |
Packaging: | 5, 25 mg in glass bottle |
Preparation Note: | U 18666A is soluble in water at 10 mg/ml. |
RIDADR | NONH for all modes of transport |
WGK Germany | WGK 3 |
Flash Point(F) | Not applicable |
Flash Point(C) | Not applicable |
Purity | ≥98% (HPLC) |
mp | 195-196.5 °C (lit.) |
Storage Temp. | 2-8°C |
UNSPSC | 12352200 |