Urokinase from human kidney cells
SIGMA/U4010 - lyophilized powder
Synonym: u-Plasminogen activator
CAS Number: 9039-53-6
EC Number: 232-917-9
MDL Number: MFCD00132566
Product Type: Chemical
This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material. This image depicts SKU: U4010-10KU
| form | lyophilized powder |
| mol wt | heavy chain 30,400 Da |
| light chain 2000 Da | |
| Quality Level | 200  |
| storage temp. | 2-8°C |
| Application: | Urokinase from human kidney cells has been used as a component of digestion mix for three-dimensional fibrin culture. It has also been used in plasminogen activation assay. |
| Biochem/physiol Actions: | Urokinase is a protease that cleaves plasminogen to form plasmin. It binds to cell surface receptors (uPAR) from which it regulates cell adhesion and migration during tissue remodeling and which also activate intracellular signaling pathways. Urokinase is composed of three domains: the amino terminal domain which is homologous to epidermal growth factor is attached through a central kringle domain to the protease domain in the carboxyl terminus. |
| Biochem/physiol Actions: | Urokinase was shown to augment proliferation of renal tumor cells. |
| Other Notes: | Note: Higher activities are obtained when human plasminogen is used as substrate. |
| Packaging: | 10000 units in poly bottle |
| Physical properties: | Supplied as a lyophilized powder containing human albumin, mannitol and NaCl. |
| Physical properties: | The principle active ingredient is the low molecular weight form of urokinase, and consists of an A chain of 2,000 daltons linked by a sulfhydyl bond to a B chain of 30,400 daltons. |
| Symbol |  GHS08 |
| Signal word | Danger |
| Hazard statements | H334 |
| Precautionary statements | P261 - P284 - P501 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Storage Temp. | 2-8°C |
| Enzyme Commission (EC) Number | 3.4.21.73 ( BRENDA  | IUBMB ) |
| UNSPSC | 12352204 |