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Urokinase from human kidney cells

SIGMA/U4010 - lyophilized powder

Synonym: u-Plasminogen activator

CAS Number: 9039-53-6
EC Number: 232-917-9
MDL Number: MFCD00132566
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-U4010-10KU 10000 units
 $298.00
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This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material. This image depicts SKU: U4010-10KU

 

form lyophilized powder
mol wt heavy chain 30,400 Da
  light chain 2000 Da
Quality Level 200 
storage temp. 2-8°C
Application: Urokinase from human kidney cells has been used as a component of digestion mix for three-dimensional fibrin culture. It has also been used in plasminogen activation assay.
Biochem/physiol Actions: Urokinase is a protease that cleaves plasminogen to form plasmin. It binds to cell surface receptors (uPAR) from which it regulates cell adhesion and migration during tissue remodeling and which also activate intracellular signaling pathways. Urokinase is composed of three domains: the amino terminal domain which is homologous to epidermal growth factor is attached through a central kringle domain to the protease domain in the carboxyl terminus.
Biochem/physiol Actions: Urokinase was shown to augment proliferation of renal tumor cells.
General description: Supplied as a lyophilized powder containing human albumin, mannitol and NaCl.
General description: The principle active ingredient is the low molecular weight form of urokinase, and consists of an A chain of 2,000 daltons linked by a sulfhydyl bond to a B chain of 30,400 daltons.
Other Notes: Note: Higher activities are obtained when human plasminogen is used as substrate.
Packaging: 10000 units in poly bottle
Symbol GHS08  GHS08
Signal word Danger
Hazard statements H334
Precautionary statements P261 - P284 - P501
RIDADR NONH for all modes of transport
WGK Germany WGK 3
Flash Point(F) Not applicable
Flash Point(C) Not applicable
Storage Temp. 2-8°C
Enzyme Commission (EC) Number 3.4.21.73   ( BRENDA  | IUBMB  )
UNSPSC 12352204

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