Urocortin human

SIGMA/U4127 - ≥85% (HPLC), powder

CAS Number: 176591-49-4
Empirical Formula (Hill Notation): C₂₀₄H₃₃₇N₆₃O₆₄
Molecular Weight: 4696.24
MDL Number: MFCD00802621
Linear Formula: C₂₀₄H₃₃₇N₆₃O₆₄
Product Type: Chemical

Catalog Number	PKG Qty.	Price	Quantity


45-U4127-250UG	250 µg	$544.00 1/EA		Add To Favorites

Properties
Descriptions
Safety Info.
Basic Data

assay	≥85% (HPLC)
biological source	human
form	powder
Quality Level	200
storage temp.	−20°C
technique(s)	ligand binding assay: suitable
UniProt accession no.	P55089

Amino Acid Sequence:	Asp-Asn-Pro-Ser-Leu-Ser-Ile-Asp-Leu-Thr-Phe-His-Leu-Leu-Arg-Thr-Leu-Leu-Glu-Leu-Ala-Arg-Thr-Gln-Ser-Gln-Arg-Glu-Arg-Ala-Glu-Gln-Asn-Arg-Ile-Ile-Phe-Asp-Ser-Val-NH2
Application:	Urocortin human can be used as a test compound for studying the impact of corticotropin-releasing factor (CRF) receptor agonist and antagonist on sleep-wake patterns in conscious rats by using radiotelemetry system.
Biochem/physiol Actions:	Binds to CRF receptor types 1, 2α, and 2β; stimulates cAMP accumulation from cells transfected with these receptors. Acts in vitro to release ACTH from rat anterior pituitary cells.
Biochem/physiol Actions:	Urocortin is a CRF-related neuropeptide having high affinity for CRF2 receptor possess appetite-suppressing effect. Urocortin along with corticotropin-releasing factor (CRF) binding protein (CRF-BP) enhances the free CRF levels in human brain by displacing hCRF from the binding protein.
Packaging:	250 μg in glass bottle

RIDADR	NONH for all modes of transport
WGK Germany	WGK 3
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable

Purity	≥85% (HPLC)
Storage Temp.	−20°C
UNSPSC	12352200

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