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Urocortin human

SIGMA/U4127 - ≥85% (HPLC), powder

CAS Number: 176591-49-4
Empirical Formula (Hill Notation): C204H337N63O64
Molecular Weight: 4696.24
MDL Number: MFCD00802621
Linear Formula: C204H337N63O64
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-U4127-250UG 250 µg
 $476.00
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assay ≥85% (HPLC)
biological source human
form powder
Quality Level 200 
storage temp. −20°C
technique(s) ligand binding assay: suitable
UniProt accession no. P55089 
Amino Acid Sequence: Asp-Asn-Pro-Ser-Leu-Ser-Ile-Asp-Leu-Thr-Phe-His-Leu-Leu-Arg-Thr-Leu-Leu-Glu-Leu-Ala-Arg-Thr-Gln-Ser-Gln-Arg-Glu-Arg-Ala-Glu-Gln-Asn-Arg-Ile-Ile-Phe-Asp-Ser-Val-NH2
Application: Urocortin human can be used as a test compound for studying the impact of corticotropin-releasing factor (CRF) receptor agonist and antagonist on sleep-wake patterns in conscious rats by using radiotelemetry system.
Biochem/physiol Actions: Binds to CRF receptor types 1, 2α, and 2β.
Biochem/physiol Actions: Binds to CRF receptor types 1, 2α, and 2β; stimulates cAMP accumulation from cells transfected with these receptors. Acts in vitro to release ACTH from rat anterior pituitary cells.
Biochem/physiol Actions: Urocortin is a CRF-related neuropeptide having high affinity for CRF2 receptor possess appetite-suppressing effect. Urocortin along with corticotropin-releasing factor (CRF) binding protein (CRF-BP) enhances the free CRF levels in human brain by displacing hCRF from the binding protein.
Packaging: 250 μg in glass bottle
RIDADR NONH for all modes of transport
WGK Germany WGK 3
Flash Point(F) Not applicable
Flash Point(C) Not applicable
Purity ≥85% (HPLC)
Storage Temp. −20°C
UNSPSC 12352200

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