UNC0638 hydrate

SIGMA/U4885 - ≥98% (HPLC)

Synonym: 2-Cyclohexyl-N-(1-isopropylpiperidin-4-yl)-6-methoxy-7-(3-(pyrrolidin-1-yl)propoxy) quinazolin-4-amine

Empirical Formula (Hill Notation): C₃₀H₄₇N₅O₂ · xH₂O
Molecular Weight: 509.73 (anhydrous basis)
MDL Number: MFCD17215972
Linear Formula: C₃₀H₄₇N₅O₂ · xH₂O
Product Type: Chemical

Catalog Number	PKG Qty.	Price


45-U4885-5MG	5 mg	$214.00 1/EA	Add To Favorites
45-U4885-25MG	25 mg	$828.00 1/EA	Add To Favorites

Properties
Descriptions
Safety Info.
Basic Data

assay	≥98% (HPLC)
color	off-white
form	solid
InChI	1S/C30H47N5O2.H2O/c1-22(2)35-17-12-24(13-18-35)31-30-25-20-27(36-3)28(37-19-9-16-34-14-7-8-15-34)21-26(25)32-29(33-30)23-10-5-4-6-11-23;/h20-24H,4-19H2,1-3H3,(H,31,32,33);1H2
InChI key	LLJGACAJGYXBTL-UHFFFAOYSA-N
Quality Level	100
SMILES string	O.COc1cc2c(NC3CCN(CC3)C(C)C)nc(nc2cc1OCCCN4CCCC4)C5CCCCC5
solubility	DMSO: >10 mg/mL
storage condition	protect from light
storage temp.	−20°C

Application:	UNC0638 has been used to block G9a (a lysine methyltransferase) function in C2C12 cells. UNC0638 has also been reported to decrease H3K9 dimethylation (H3K9me2) levels and inhibit cell death in hair cells.
Application:	UNC0638 hydrate has been used: • in fractionation and isolation of human blood cells and cell nuclei • in the analysis of human immunodeficiency virus (HIV) reactivation in latently infected cell line • to determine the effect of G9a and its enzymatic activity on cisplatin resistance
Biochem/physiol Actions:	UNC0638 hydrate is a histone methyltransferase (HMT) inhibitor. UNC0638 shows selectivity for G9a (EHMT2) and GLP (EHMT1) methyltransferases, which catalyze the methylation of lysine 9 of histone 3 (H3K9) as well as other non-histone substrates. For full characterization details, please visit the UNC0638 probe summary on the Structural Genomics Consortium (SGC) website. To learn about other SGC chemical probes for epigenetic targets, visit sigma.com/sgc
Features and Benefits:	This compound is a featured product for Gene Regulation research. Click here to discover more featured Gene Regulation products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm .
Features and Benefits:	UNC0638 is an epigenetic chemical probe available through a partnership with the Structural Genomics Consortium (SGC). To learn more and view other SGC epigenetic probes, visit sigma.com/SGC .
General description:	UNC0638 enhances the E-cadherin expression in gemcitabine-resistant cell line (PANC-1-R).
Other Notes:	UNC0638 has been expertly reviewed and recommended by the Chemical Probes Portal. For more information, please visit the UNC0638 probe summary on the Chemical Probes Portal website.
Packaging:	5, 25 mg in glass bottle

Symbol	GHS06
Signal word	Danger
Hazard statements	H300 - H413
Precautionary statements	P273 - P301 + P310 + P330
Hazard Codes	T
Risk Statements	25
Safety Statements	45
RIDADR	UN 2811 6.1 / PGIII
WGK Germany	WGK 3
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable

Purity	≥98% (HPLC)
Storage Temp.	−20°C
UNSPSC	12352200

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