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Uracil 1-β-D-arabinofuranoside

SIGMA/U5377 - lymphoma antiproliferative

Synonym: Arauridine; Spongouridin; 1-β-D-Arabinofuranosyluracil

CAS Number: 3083-77-0
Empirical Formula (Hill Notation): C9H12N2O6
Molecular Weight: 244.20
EC Number: 221-386-9
MDL Number: MFCD00065998
Linear Formula: C9H12N2O6
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-U5377-250MG 250 mg
 $579.00
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This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material. This image depicts SKU: U5377-250MG

 

assay ≥98% (HPLC)
biological source synthetic (organic)
form powder
InChI 1S/C9H12N2O6/c12-3-4-6(14)7(15)8(17-4)11-2-1-5(13)10-9(11)16/h1-2,4,6-8,12,14-15H,3H2,(H,10,13,16)/t4-,6-,7+,8-/m1/s1
InChI key DRTQHJPVMGBUCF-CCXZUQQUSA-N
Quality Level 200 
SMILES string OC[C@H]1O[C@H]([C@@H](O)[C@@H]1O)N2C=CC(=O)NC2=O
solubility water: 50 mg/mL, clear, colorless
storage temp. −20°C
Application: Uracil 1-β-D-arabinofuranoside may be used as a reference compound in the analysis of cytostatics and metabolites in hospital wastewater by hydrophilic interaction chromatography/tandem mass spectrometry to demonstrate its analytical possibilities and limitations. It may also be used as a standard for chemical analysis to investigate the ecotoxicity and genotoxicity of cytotoxic antineoplastic drugs, like cytarabine (CYT) and their metabolites, like uracil-1-β-d-arabinofuranoside (AraU).
Biochem/physiol Actions: 1-β-D-Arabinofuranosyluracil (ara-U) is capable of inhibiting proliferation of L5178Y mouse lymphoma cells at 17 μM concentration.
General description: 1-β-d-arabinofuranosyluracil (Ara-U) is the detoxification product or metabolite of 1-β-d-arabinofuranosylcytosine (Ara-C). Uracil 1-β-D-arabinofuranoside is the human metabolite of a cytostatic agent called cytarabine (CYT).
Packaging: 1 g in poly bottle
Packaging: 250 mg in poly bottle
RIDADR NONH for all modes of transport
WGK Germany WGK 3
Flash Point(F) Not applicable
Flash Point(C) Not applicable
Purity ≥98% (HPLC)
Storage Temp. −20°C
UNSPSC 41106305

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