UCN-01
SIGMA/U6508 - ≥97% (HPLC), powder
Synonym: KW-2401
CAS Number: 112953-11-4
Empirical Formula (Hill Notation): C28H26N4O4
Molecular Weight: 482.53
MDL Number: MFCD26960886
Linear Formula: C28H26N4O4
Product Type: Chemical
assay | ≥97% (HPLC) |
color | light yellow |
form | powder |
optical activity | [α]20/D 130 to 160°, c = 0.2 in DMSO |
Quality Level | 100 ![]() |
SMILES string | [H][C@@]1(C[C@@H](NC)[C@H |
solubility | DMSO: >5 mg/mL |
H2O: insoluble | |
storage condition | protect from light |
storage temp. | 2-8°C |
Application: | UCN-01 has been used to study checkpoint kinase-1 (CHK1) protein function in trophoblast stem (TS) cells. It has also been used to study UV-induced CHK1 phosphorylation in IB10 cells. |
Biochem/physiol Actions: | UCN-01 is a selective inhibitor for conventional PKC isotypes over novel PKC isotypes. |
Features and Benefits: | This compound is featured on the PKB/Akt ![]() ![]() ![]() |
Packaging: | 1, 5 mg in glass bottle |
Preparation Note: | UCN-01 is soluble in DMSO at a concentration that is greater than 5 mg/ml. However, it is insoluble in water. |
RIDADR | NONH for all modes of transport |
WGK Germany | WGK 3 |
Flash Point(F) | Not applicable |
Flash Point(C) | Not applicable |
Purity | ≥97% (HPLC) |
Storage Temp. | 2-8°C |
UNSPSC | 12352200 |