Urocortin rat
SIGMA/U6631 - ≥97% (HPLC), powder
CAS Number: 171543-83-2
Empirical Formula (Hill Notation): C206H338N62O64
Molecular Weight: 4707.26
MDL Number: MFCD00678232
Linear Formula: C206H338N62O64
Product Type: Chemical
| assay | ≥97% (HPLC) |
| biological source | rat |
| form | powder |
| Quality Level | 200  |
| solubility | 1% acetic acid: >1 mg/mL, clear, colorless |
| storage temp. | −20°C |
| technique(s) | western blot: suitable |
| UniProt accession no. | P55090  |
| Amino Acid Sequence: | Asp-Asp-Pro-Pro-Leu-Ser-I |
| Application: | Urocortin rat can be used for western blotting. The product can also be used for studying that whether CRF receptor type 2 (CRF2) and its high-affinity ligand, urocortin 1 (Ucn1) can mediate sex-specific cellular stress responses by using corticotropin-releasing factor receptor 2-deficient (Crhr2-/- ) and wild-type (WT) mice. |
| Biochem/physiol Actions: | Binds to CRF receptor types 1, 2α, and 2β; stimulates cAMP accumulation from cells transfected with these receptors. Acts in vitro to release ACTH from rat anterior pituitary cells. |
| Biochem/physiol Actions: | Urocortin is a CRF-related neuropeptide that binds to CRF receptor types 1α, 2α and 2β. It possesses appetite-suppressing effect. Urocortin along with corticotropin-releasing factor (CRF) binding protein (CRF-BP) enhances the free CRF levels in human brain by displacing hCRF from the binding protein. |
| Other Notes: | Lyophilized from 0.1% TFA in H2O |
| Preparation Note: | Urocortin rat dissolves in 1% acetic acid at 1 mg/ml to yield a clear, colorless solution. |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Purity | ≥97% (HPLC) |
| Storage Temp. | −20°C |
| UNSPSC | 12352200 |