Synonym: 1-[6-[((17β)-3-Methoxyestra-1,3,5[10]-trien-17-yl)amino]hexyl]-1H-pyrrole-2,5-dione
CAS Number: 112648-68-7 (anhydrous)
Empirical Formula (Hill Notation): C29H40N2O3 · xH2O
Molecular Weight: 464.64 (anhydrous basis)
MDL Number: MFCD12910450
Linear Formula: C29H40N2O3 · xH2O
Product Type: Chemical
| assay |
≥97.5% (HPLC) |
| color |
off-white |
| form |
powder |
| InChI |
1S/C29H40N2O3.H2O/c1-29-16-15-23-22-10-8-21(34-2)19-20(22)7-9-24(23)25(29)11-12-26(29)30-17-5-3-4-6-18-31-27(32)13-14-28(31)33;/h8,10,13-14,19,23-26,30H,3-7,9,11-12,15-18H2,1-2H3;1H2/t23-,24-,25+,26+,29+;/m1./s1 |
| InChI key |
WCOYJDRCHHGMRK-BDEPKWELSA-N |
| Quality Level |
100  |
| SMILES string |
O.COc1ccc2C3CC[C@]4(C)[C@H](CCC4C3CCc2c1)NCCCCCCN5C(=O)C=CC5=O |
| solubility |
chloroform: ~10 mg/mL |
| |
DMSO: ≤2.6 mg/mL (Achieved with heating.) |
| |
DMSO: ~0.9 mg/mL |
| |
ethanol: ≤5 mg/mL (Achieved with heating.) |
| |
ethanol: ~0.7 mg/mL |
| |
H2O: insoluble |
| storage temp. |
room temp |
| Application: |
U-73122 hydrate has been used for studying the role of phospholipase C (PLC) signaling in modulating epithelial Na+ channel (ENaC) function in gerbil Reissner′s membranes (RMs). U-73122 has also been used to study local calcium responses in human umbilical vein endothelial cells (HUVECs). |
| Biochem/physiol Actions: |
Inhibits the hydrolysis of PPI to IP3, which leads to a decrease in cytosolic free calcium. Inhibits the coupling of G protein-phospholipase C activation, while remaining unaffected by production of cAMP. |
| Features and Benefits: |
This compound is featured on the Phospholipase C page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here . |
| Packaging: |
5 mg in glass bottle |
| Preparation Note: |
U-73122 hydrate is soluble in ethanol (approx. 0.7 mg/ml or ≤ 5 mg/ml with heating), chloroform (approx. 10 mg/ml) and DMSO (approx. 0.9 mg/ml or ≤ 2.6 mg/ml with heating). U-73122 hydrate is insoluble in water. |
| Hazard Codes |
Xi |
| Risk Statements |
36/37/38 |
| Safety Statements |
26-36 |
| RIDADR |
NONH for all modes of transport |
| WGK Germany |
WGK 3 |
| Flash Point(F) |
Not applicable |
| Flash Point(C) |
Not applicable |
| Purity |
≥97.5% (HPLC) |
| Storage Temp. |
room temp |
| UNSPSC |
41106300 |
