Uridine 5′-triphosphate tris salt

SIGMA/U6875 - Type VI, ≥90%

Synonym: UTP

CAS Number: 108321-53-5
Empirical Formula (Hill Notation): C₉H₁₅N₂O₁₅P₃
Molecular Weight: 484.14
MDL Number: MFCD00058360
Linear Formula: C₉H₁₅N₂O₁₅P₃
Product Type: Chemical

Catalog Number	PKG Qty.	Price


45-U6875-100MG	100 mg	$171.00 1/EA	Add To Favorites
45-U6875-500MG	500 mg	$681.00 1/EA	Add To Favorites

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Properties
Descriptions
Safety Info.
Basic Data

assay	≥90%
InChI	1S/C9H15N2O15P3.C4H11NO3/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(24-8)3-23-28(19,20)26-29(21,22)25-27(16,17)18;5-4(1-6,2-7)3-8/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H,21,22)(H,10,12,15)(H2,16,17,18);6-8H,1-3,5H2/t4-,6-,7-,8-;/m1./s1
InChI key	NHMNWWVJZZPKSL-IAIGYFSYSA-N
Quality Level	200
shipped in	dry ice
SMILES string	NC(CO)(CO)CO.O[C@H]1[C@@H](O)[C@@H](O[C@@H]1COP(O)(=O)OP(O)(=O)OP(O)(O)=O)N2C=CC(=O)NC2=O
solubility	H₂O: soluble 50 mg/mL, clear, colorless
storage temp.	−20°C
type	Type VI

Application:	Uridine 5′-triphosphate tris salt has been used: • to investigate its activation potential on the purinergic P2Y2 Receptor in THP1 monocytes • as a component of non-radioactive nucleoside triphosphate solution used in in vitro RNA polymerase assay • as a P2Y2 agonist in human embryonic kidney cells (HEK293T) in dynamic mass redistribution (DMR) assays
Application:	UTP has been used to study intracellular Ca²⁺ concentration in alveolar type II (AT2) cells. UTP has also been used as a phosphate donor for in vitro kinase assays using deoxycytidine kinase (DCK) or whole cell lysates.
Biochem/physiol Actions:	P2Y receptor agonist.
Biochem/physiol Actions:	Uridine 5′-triphosphate (UTP) is synthesized from uridine 5′-diphosphate (UDP) in the presence of the enzyme nucleoside diphosphate kinase (NDPK). Plant cells have high uridine as UTP. UTP on amination results in the generation of CTP and is catalysed by enzyme CTP synthetase. UTP acts on the purinergic (P2Y2) receptor and mediates smooth muscle cells (SMCs) mitogenic activation. It also modulates osteopontin expression in SMCs. UTP is a sputum inducer and a promising candidate for assessing the inflammation in respiratory airway.
Packaging:	100, 500 mg in poly bottle
Preparation Note:	Uridine 5′-triphosphate (UTP) tris salt is soluble in water at 50 mg/ml and yields a clear, colorless solution.

RIDADR	NONH for all modes of transport
WGK Germany	WGK 3
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable

Purity	≥90%
Storage Temp.	−20°C
UNSPSC	12352200

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