Synonym: 1-[6-[((17β)-3-Methoxyestra-1,3,5[10]-trien-17-yl)amino]hexyl]-2,5-pyrrolidinedione
CAS Number: 142878-12-4
Empirical Formula (Hill Notation): C29H42N2O3
Molecular Weight: 466.66
MDL Number: MFCD00211221
Linear Formula: C29H42N2O3
Product Type: Chemical
| assay |
≥98% (HPLC) |
| color |
white |
| form |
powder |
| InChI |
1S/C29H42N2O3/c1-29-16-15-23-22-10-8-21(34-2)19-20(22)7-9-24(23)25(29)11-12-26(29)30-17-5-3-4-6-18-31-27(32)13-14-28(31)33/h8,10,19,23-26,30H,3-7,9,11-18H2,1-2H3/t23-,24-,25+,26+,29+/m1/s1 |
| InChI key |
CJHWFIUASFBCKN-ZRJUGLEFSA-N |
| Quality Level |
200  |
| SMILES string |
[H][C@]12CC[C@]3(C)[C@H](CC[C@@]3([H])[C@]1([H])CCc4cc(OC)ccc24)NCCCCCCN5C(=O)CCC5=O |
| solubility |
DMSO: soluble |
| Application: |
U-73343 has been used for studying the role of phospholipase C (PLC) signaling in modulating epithelial Na+ channel (ENaC) function in gerbil Reissner′s membranes (RMs). U-73343 has also been used as a negative control for PLC inhibition in mechanically stimulated (MS) and its neighboring (NB) cells. |
| Application: |
U-73343 has been used in measuring the fluorescence of intracellular Ca2+. |
| Biochem/physiol Actions: |
Inactive analog of U73122; used as a negative control. |
| General description: |
U-73343 is used to assess the involvement of G protein-coupled 1-phosphatidylinositol-phosphodiesterase or phospholipase C in receptor-mediated cell activation. It functions downstream of phospholipase C to block receptor-mediated phospholipase D activation. |
| Packaging: |
1, 5 mg in glass bottle |
| Preparation Note: |
U-73343 is soluble in chloroform at 10 mg/ml and yields a clear, colorless to faint yellow solution. It is also soluble in ethanol (0.93 mg/ml) and DMSO (2.3 mg/ml), but is insoluble in water. |
| Hazard Codes |
Xi |
| Risk Statements |
36/37/38 |
| Safety Statements |
26-36 |
| RIDADR |
NONH for all modes of transport |
| WGK Germany |
WGK 3 |
| Flash Point(F) |
Not applicable |
| Flash Point(C) |
Not applicable |
| Purity |
≥98% (HPLC) |
| UNSPSC |
41106300 |
