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Uricase from Arthrobacter globiformis

SIGMA/U7128 - lyophilized powder, 15-30 units/mg protein (biuret)

Synonym: Urate oxidase; Urate:O2 oxidoreductase

CAS Number: 9002-12-4
EC Number: 232-655-5
MDL Number: MFCD00082126
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-U7128-100UN 100 units
 $729.00
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form lyophilized powder
InChI 1S/C18H23N4O14P.H3N/c23-5-7-14(13(28)16(34-7)22-4-2-10(25)20-18(22)30)36-37(31,32)33-6-8-11(26)12(27)15(35-8)21-3-1-9(24)19-17(21)29;/h1-4,7-8,11-16,23,26-28H,5-6H2,(H,31,32)(H,19,24,29)(H,20,25,30);1H3
InChI key VPXDHZMLJOJKOX-UHFFFAOYSA-N
mol wt tetramer ~32 kDa
Quality Level 200 
specific activity 15-30 units/mg protein (biuret)
storage temp. −20°C
Application: Uricase from Arthrobacter globiformis has been used for coating the electrodes in - biosensor fabrication for the detection of uric acid in urine samples. It has also been used for analysing the effect of Zn, Cu, Mg, and Mn ions on uricase.
Biochem/physiol Actions: Arthrobacter globiformis is a major producer of uricase or urate oxidase in the poultry manure and litter. Uricase hydrolyzes uric acid and causes ammonia volatilization in poultry manure. In the majority of mammals, uricase converts uric acid to allantoin, a soluble excretion product. Humans lack uricase due to its loss during the evolution of hominids. This increases the risk of humans towards gout, kidney stone, hypertension and diabetes due to increased circulating levels of uric acid.
Biochem/physiol Actions: Molecular weight: 4 × ~32 KDa (tetramer)
Isoelectric point: is 4.64
KM value (uric acid as substrate): ~ 0.01 mM
The optimum pH for activity: 8.5-9.5
The optimum pH for stability: 6.0-9.5
Biochem/physiol Actions: Zn and Cu were shown to inhibit the activity of uricase.
Packaging: 100 units in serum bottle
Unit Definition: One unit will convert 1.0 μmole of uric acid to allantoin per min at pH 9.0 at 25 °C.
activity specific activity: 15-30 units/mg protein (biuret)
Storage Temp. −20°C
Enzyme Commission (EC) Number 1.7.3.3   ( BRENDA  | IUBMB  )
UNSPSC 12352204

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