Urotensin II human
SIGMA/U7257 - ≥97% (HPLC), synthetic
CAS Number: 251293-28-4
Empirical Formula (Hill Notation): C64H85N13O18S2
Molecular Weight: 1388.57
MDL Number: MFCD04115626
Linear Formula: C64H85N13O18S2
Product Type: Chemical
assay | ≥97% (HPLC) |
biological source | synthetic |
form | lyophilized powder |
InChI | 1S/C64H85N13O18S2/c1-33(2 |
InChI key | HFNHAPQMXICKCF-USJMABIRSA |
Quality Level | 200 ![]() |
SMILES string | CC(C)[C@H](NC(=O)[C@@H]1C |
storage temp. | −20°C |
technique(s) | calcium flux assay: suitable |
UniProt accession no. | O95399 ![]() ![]() |
Amino Acid Sequence: | Glu-Thr-Pro-Asp-Cys-Phe-T |
Application: | Urotensin II human was used in agonist and antagonist preparation for calcium mobilization assay. The product can also be used as a test compound for studying the impact of dihydropyridine calcium antagonist amlodipine in human internal mammary artery and clinical implications. |
Biochem/physiol Actions: | A neuroendocrine peptide of the CRF family that was originally isolated from fish brain but is also found in mammalian brain and spinal motor neurons. It is a potent vasoconstrictor. It may be a mediator of stress-induced anorexia. |
Biochem/physiol Actions: | Human urotensin II is a vasoactive neuropeptide that belongs to CRF family and stimulates arterial smooth muscle contraction, actin stress fiber formation and proliferation via small GTPase RhoA and there downstream effector Rho-kinase activation.The product is also a selective and potent vasoconstrictor agent as well as an agonist for the orphan receptor GPR14. |
Other Notes: | Lyophilized from 0.1% TFA in H2O |
Packaging: | 0.5, 1 mg in poly bottle |
RIDADR | NONH for all modes of transport |
WGK Germany | WGK 3 |
Flash Point(F) | Not applicable |
Flash Point(C) | Not applicable |
Purity | ≥97% (HPLC) |
Storage Temp. | −20°C |
UNSPSC | 12352200 |