Synonym: 6,12,19,20,25,26-hexahydro- 5,27:13,18:21,24-Trietheno-11,7-metheno-7H-dibenzo[b,m][1,5,12,16]tetraazacyclotricosine-5,13-diium ditrifluoroacetate hydrate
CAS Number: 201147-19-5 (anhydrous)
Empirical Formula (Hill Notation): C38H30F6N4O4 · xH2O
Molecular Weight: 720.66 (anhydrous basis)
Linear Formula: (C34H30N4)2+ · (C2F3O2-)2 · xH2O
Product Type: Chemical
color |
white to off-white |
InChI |
1S/C34H28N4.2C3H3F3O2.H2O/c1-3-10-33-29(8-1)31-16-18-37(33)23-27-6-5-7-28(20-27)24-38-19-17-32(30-9-2-4-11-34(30)38)36-22-26-14-12-25(13-15-26)21-35-31;2*4-3(5,6)1-2(7)8;/h1-20H,21-24H2;2*1H2,(H,7,8);1H2/b35-31+,36-32+;;; |
InChI key |
YROHEYZVNZITJN-DDVHGCDCSA-N |
Quality Level |
100 ![External link](https://krackeler.com/images/sigma/ext-link.gif) |
SMILES string |
[H]O[H].FC(F)(C(O)=O)F.FC(F)(C(O)=O)F.C12=CC=CC=C1C(NCC3=CC=C(CNC4=CC=[N+](C5)C6=C4C=CC=C6)C=C3)=CC=[N+]2CC7=CC=CC5=C7 |
solubility |
DMSO: 10 mg/mL |
Application: |
UCL 1684 ditrifluoroacetate hydrate has been used for analyzing the mechanism for ammonium-mediated displacement of the protonated analyte from analyte-trifluoroacetic acid (TFA) ion-pair. UCL 1684 has also been used as a potassium channel inhibitor to study CNP (C-type natriuretic peptide)-induced relaxations in pig coronary arteries. |
Biochem/physiol Actions: |
UCL 1684 is a potent non-peptide blocker of the apamin-sensitive Ca2+-activated K+ channel. It comprises two quinolinium rings and is similar to apamin arginine residue. UCL 1684 inhibits calcium-activated K current (Kslow) and modulates islet β-cell. |
Features and Benefits: |
This compound is featured on the Potassium Channels page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here . |
Packaging: |
5, 25 mg in glass bottle |
Preparation Note: |
UCL 1684 ditrifluoroacetate hydrate is soluble in water at 10 mg/ml. |
RIDADR |
NONH for all modes of transport |
WGK Germany |
WGK 3 |
Flash Point(F) |
Not applicable |
Flash Point(C) |
Not applicable |