Ubiquitin-Carrier Protein H5c human
SIGMA/U8882 - ≥95% (SDS-PAGE), recombinant, expressed in E. coli (GST-tagged), solution
Synonym: UbcH5c
MDL Number: MFCD03458909
Product Type: Chemical
| assay | ≥95% (SDS-PAGE) |
| biological source | human |
| form | solution |
| mol wt | 47 kDa |
| Quality Level | 200  |
| recombinant | expressed in E. coli (GST-tagged) |
| shipped in | dry ice |
| storage temp. | −70°C |
| technique(s) | ligand binding assay: suitable |
| UniProt accession no. | P61077  |
| Application: | Ubiquitin-Carrier Protein H5c human may be used to study ubiquitin-proteasome system and its role in pathogenesis of human diseases. |
| Biochem/physiol Actions: | Mediates the degradation of a myriad of short-lived regulatory proteins including the tumor suppressor p53 in the presence of E6/E6-AP or MDM2, the c-Fos transcription factor, and the signal-induced ubiquitination of IκBα, UBC5 is an essential gene in yeast. |
| Biochem/physiol Actions: | Ubiquitin-Carrier Protein H5c human also referred to as UbcH5c is a recombinant protein that interacts with ZIPK and stimulate its ubiquitination and hence facilitates in regulating ZIPK accumulation in promyelocytic leukemia protein nuclear body (PML-NBs). |
| General description: | Manufactured for Sigma by Boston Biochem., Inc. |
| Physical form: | Solution in 50 mM HEPES, pH 7.6, 50 mM NaCl, 1 mM DTT in 10% glycerol. |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 2 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Purity | ≥95% (SDS-PAGE) |
| Storage Temp. | −70°C |
| UNSPSC | 12352200 |