4-Hydroxymephenytoin
SIGMA/UC126
Synonym: (±)
CAS Number: 61837-65-8
Empirical Formula (Hill Notation): C12H14N2O3
Molecular Weight: 234.25
MDL Number: MFCD00142316
Linear Formula: C12H14N2O3
Product Type: Chemical
color | white |
form | solid |
InChI | 1S/C12H14N2O3/c1-3-12(8-4 |
InChI key | OQPLORUDZLXXPD-UHFFFAOYSA |
mp | 153-154 °C |
Quality Level | 200 ![]() |
SMILES string | CCC1(NC(=O)N(C)C1=O)c2ccc |
storage temp. | 2-8°C |
Application: | 4-Hydroxymephenytoin has been used for developing ultra performance LC (UPLC)- tandem mass spectrometry (MS/MS) assays for evaluating cytochrome P450 (CYP) probe drugs and their relevant metabolites in human urine or plasma samples. 4-hydroxymephenytoin has also been used for developing sub-2-micron particle LC/MS/MS-based methods for analyzing CYP450 probe substrate metabolites. |
Biochem/physiol Actions: | 4-Hydroxymephenytoin catabolism displays genetic polymorphism and is a direct indicator of Cytochrome P450 2C19 (CYP2C19) activity. Detection and quantification of 4-hydroxymephenytoin in biological samples by HPLC method is well optimized. |
General description: | CYP2C19 metabolite of mephenytoin. |
Packaging: | 5, 10 mg in glass bottle |
Packaging: | Bottomless glass bottle. Contents are inside inserted fused cone. |
RIDADR | NONH for all modes of transport |
WGK Germany | WGK 3 |
Flash Point(F) | Not applicable |
Flash Point(C) | Not applicable |
mp | 153-154 °C |
Storage Temp. | 2-8°C |
UNSPSC | 12161501 |